Stearoyl-CoA desaturase (hSCD1) (EC 1.14.19.1) (Acyl-CoA desaturase) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase)
1_MPAHL 6_ LQDDI 11_ SSSYT 16_ TTTTI 21_ TAPPS 26_ RVLQN 31_ GGDKL 36_ ETMPL 41_ YLEDD 46_ IRPDI 51_ KDDIY 56_ DPTYK 61_ DKEGP 66_ SPKVE 71_ YVWRN 76_ IILMS 81_ LLHLG 86_ ALYGI 91_ TLIPT 96_ CKFYT 101_ WLWGV 106_ FYYFV 111_ SALGI 116_ TAGAH 121_ RLWSH 126_ RSYKA 131_ RLPLR 136_ LFLII 141_ ANTMA 146_ FQNDV 151_ YEWAR 156_ DHRAH 161_ HKFSE 166_ THADP 171_ HNSRR 176_ GFFFS 181_ HVGWL 186_ LVRKH 191_ PAVKE 196_ KGSTL 201_ DLSDL 206_ EAEKL 211_ VMFQR 216_ RYYKP 221_ GLLMM 226_ CFILP 231_ TLVPW 236_ YFWGE 241_ TFQNS 246_ VFVAT 251_ FLRYA 256_ VVLNA 261_ TWLVN 266_ SAAHL 271_ FGYRP 276_ YDKNI 281_ SPREN 286_ ILVSL 291_ GAVGE 296_ GFHNY 301_ HHSFP 306_ YDYSA 311_ SEYRW 316_ HINFT 321_ TFFID 326_ CMAAL 331_ GLAYD 336_ RKKVS 341_ KAAIL 346_ ARIKR 351_TGDGN
1: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity)