SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
1_MNGAG 6_ PGPAA 11_ AAPVP 16_ VPVPV 21_ PDWRQ 26_ FCELH 31_ AQAAA 36_ VDFAH 41_ KFCRF 46_ LRDNP 51_ AYDTP 56_ DAGAS 61_ FSRHF 66_ AANFL 71_ DVFGE 76_ EVRRV 81_ LVAGP 86_ TTRGA 91_ AVSAE 96_ AMEPE 101_ LADTS 106_ ALKAA 111_ PYGHS 116_ RSSED 121_ VSTHA 126_ ATKAR 131_ VRKGF 136_ SLRNM 141_ SLCVV 146_ DGVRD 151_ MWHRR 156_ ASPEP 161_ DAAAA 166_ PRTAE 171_ PRDKW 176_ TRRLR 181_ LSRTL 186_ AAKVE 191_ LVDIQ 196_ REGAL 201_ RFMVA 206_ DDAAA 211_ GSGGS 216_ AQWQK 221_ CRLLL 226_ RRAVA 231_ EERFR 236_ LEFFV 241_ PPKAS 246_ RPKVS 251_ IPLSA 256_ IIEVR 261_ TTMPL 266_ EMPEK 271_ DNTFV 276_ LKVEN 281_ GAEYI 286_ LETID 291_ SLQKH 296_ SWVAD 301_ IQGCV 306_ DPGDS 311_ EEDTE 316_ LSCTR 321_ GGCLA 326_ SRVAS 331_ CSCEL 336_ LTDAV 341_ DLPRP 346_ PETTA 351_ VGAVV 356_ TAPHS 361_ RGRDA 366_ VRESL 371_ IHVPL 376_ ETFLQ 381_ TLESP 386_ GGSGS 391_ DSNNT 396_ GEQGA 401_ ETDPE 406_ AEPEL 411_ ELSDY 416_ PWFHG 421_ TLSRV 426_ KAAQL 431_ VLAGG 436_ PRNHG 441_ LFVIR 446_ QSETR 451_ PGEYV 456_ LTFNF 461_ QGKAK 466_ HLRLS 471_ LNGHG 476_ QCHVQ 481_ HLWFQ 486_ SVLDM 491_ LRHFH 496_ THPIP 501_ LESGG 506_ SADIT 511_ LRSYV 516_ RAQDP 521_ PPEPG 526_ PTPPA 531_ APASP 536_ ACWSD 541_ SPGQH 546_ YFSSL 551_ AAAAC 556_ PPASP 561_ SDAAG 566_ ASSSS 571_ ASSSS 576_ AASGP 581_ APPRP 586_ VEGQL 591_ SARSR 596_ SNSAE 601_ RLLEA 606_ VAATA 611_ AEEPP 616_ EAAPG 621_ RARAV 626_ENQYS
1: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3