Claudin-4 (Clostridium perfringens enterotoxin receptor) (CPE-R) (CPE-receptor) (Williams-Beuren syndrome chromosomal region 8 protein)
1_MASMG 6_ LQVMG 11_ IALAV 16_ LGWLA 21_ VMLCC 26_ ALPMW 31_ RVTAF 36_ IGSNI 41_ VTSQT 46_ IWEGL 51_ WMNCV 56_ VQSTG 61_ QMQCK 66_ VYDSL 71_ LALPQ 76_ DLQAA 81_ RALVI 86_ ISIIV 91_ AALGV 96_ LLSVV 101_ GGKCT 106_ NCLED 111_ ESAKA 116_ KTMIV 121_ AGVVF 126_ LLAGL 131_ MVIVP 136_ VSWTA 141_ HNIIQ 146_ DFYNP 151_ LVASG 156_ QKREM 161_ GASLY 166_ VGWAA 171_ SGLLL 176_ LGGGL 181_ LCCNC 186_ PPRTD 191_ KPYSA 196_ KYSAA 201_RSAAA
1: Can associate with other claudins to regulate tight junction structural and functional strand dynamics (PubMed:35773259, PubMed:36008380). May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:36008380). May integrate into CLDN3 strands to modulate localized tight junction barrier properties (PubMed:35773259, PubMed:36008380). May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance (PubMed:35773259, PubMed:36008380). Cannot form tight junction strands on its own (PubMed:35773259, PubMed:36008380)