Phospholipid phosphatase 1 (EC 3.1.3.-) (EC 3.1.3.106) (EC 3.1.3.4) (EC 3.1.3.81) (Lipid phosphate phosphohydrolase 1) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a)
1_MFDKT 6_ RLPYV 11_ ALDVL 16_ CVLLA 21_ GLPFA 26_ ILTSR 31_ HTPFQ 36_ RGVFC 41_ NDESI 46_ KYPYK 51_ EDTIP 56_ YALLG 61_ GIIIP 66_ FSIIV 71_ IILGE 76_ TLSVY 81_ CNLLH 86_ SNSFI 91_ RNNYI 96_ ATIYK 101_ AIGTF 106_ LFGAA 111_ ASQSL 116_ TDIAK 121_ YSIGR 126_ LRPHF 131_ LDVCD 136_ PDWSK 141_ INCSD 146_ GYIEY 151_ YICRG 156_ NAERV 161_ KEGRL 166_ SFYSG 171_ HSSFS 176_ MYCML 181_ FVALY 186_ LQARM 191_ KGDWA 196_ RLLRP 201_ TLQFG 206_ LVAVS 211_ IYVGL 216_ SRVSD 221_ YKHHW 226_ SDVLT 231_ GLIQG 236_ ALVAI 241_ LVAVY 246_ VSDFF 251_ KERTS 256_ FKERK 261_ EEDSH 266_ TTLHE 271_ TPTTG 276_NHYPS
1: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:10962286, PubMed:17379599, PubMed:9305923, PubMed:9607309, PubMed:9705349). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity)