Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein)
1_MERIP 6_ SAQPP 11_ PACLP 16_ KAPGL 21_ EHGDL 26_ PGMYP 31_ AHMYQ 36_ VYKSR 41_ RGIKR 46_ SEDSK 51_ ETYKL 56_ PHRLI 61_ EKKRR 66_ DRINE 71_ CIAQL 76_ KDLLP 81_ EHLKL 86_ TTLGH 91_ LEKAV 96_ VLELT 101_ LKHVK 106_ ALTNL 111_ IDQQQ 116_ QKIIA 121_ LQSGL 126_ QAGEL 131_ SGRNV 136_ ETGQE 141_ MFCSG 146_ FQTCA 151_ REVLQ 156_ YLAKH 161_ ENTRD 166_ LKSSQ 171_ LVTHL 176_ HRVVS 181_ ELLQG 186_ GTSRK 191_ PSDPA 196_ PKVMD 201_ FKEKP 206_ SSPAK 211_ GSEGP 216_ GKNCV 221_ PVIQR 226_ TFAHS 231_ SGEQS 236_ GSDTD 241_ TDSGY 246_ GGESE 251_ KGDLR 256_ SEQPC 261_ FKSDH 266_ GRRFT 271_ MGERI 276_ GAIKQ 281_ ESEEP 286_ PTKKN 291_ RMQLS 296_ DDEGH 301_ FTSSD 306_ LISSP 311_ FLGPH 316_ PHQPP 321_ FCLPF 326_ YLIPP 331_ SATAY 336_ LPMLE 341_ KCWYP 346_ TSVPV 351_ LYPGL 356_ NASAA 361_ ALSSF 366_ MNPDK 371_ ISAPL 376_ LMPQR 381_ LPSPL 386_ PAHPS 391_ VDSSV 396_ LLQAL 401_ KPIPP 406_LNLET
1: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:12397359, PubMed:18411297). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (PubMed:15193144). Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (PubMed:15560782). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706). Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558). May be involved in the regulation of chondrocyte differentiation via the cAMP pathway (PubMed:19786558). Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (PubMed:28797635). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868)