Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
1_MTLRC 6_ LEPSG 11_ NGGEG 16_ TRSQW 21_ GTAGS 26_ AEEPS 31_ PQAAR 36_ LAKAL 41_ RELGQ 46_ TGWYW 51_ GSMTV 56_ NEAKE 61_ KLKEA 66_ PEGTF 71_ LIRDS 76_ SHSDY 81_ LLTIS 86_ VKTSA 91_ GPTNL 96_ RIEYQ 101_ DGKFR 106_ LDSII 111_ CVKSK 116_ LKQFD 121_ SVVHL 126_ IDYYV 131_ QMCKD 136_ KRTGP 141_ EAPRN 146_ GTVHL 151_ YLTKP 156_ LYTSA 161_ PSLQH 166_ LCRLT 171_ INKCT 176_ GAIWG 181_ LPLPT 186_ RLKDY 191_LEEYK
1: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR (PubMed:11781573, PubMed:21980433, PubMed:25505247, PubMed:31182716, PubMed:34857742). Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (PubMed:21980433, PubMed:25505247, PubMed:31182716, PubMed:34857742, PubMed:37816714). The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2 (PubMed:21980433, PubMed:25505247, PubMed:34857742). The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR (PubMed:11781573)