Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]
1_MRQVC 6_ CSALP 11_ PPPLE 16_ KGRCS 21_ SYSDS 26_ SSSSS 31_ ERSSS 36_ SSSSS 41_ SESGS 46_ SSRSS 51_ SNNSS 56_ ISRPA 61_ APPEP 66_ RPQQQ 71_ PQPRS 76_ PAARR 81_ AAARS 86_ RAAAA 91_ GGMRR 96_ DPAPG 101_ FSMLL 106_ FGVSL 111_ ACYSP 116_ SLKSV 121_ QDQAY 126_ KAPVV 131_ VEGKV 136_ QGLVP 141_ AGGSS 146_ SNSTR 151_ EPPAS 156_ GRVAL 161_ VKVLD 166_ KWPLR 171_ SGGLQ 176_ REQVI 181_ SVGSC 186_ VPLER 191_ NQRYI 196_ FFLEP 201_ TEQPL 206_ VFKTA 211_ FAPLD 216_ TNGKN 221_ LKKEV 226_ GKILC 231_ TDCAT 236_ RPKLK 241_ KMKSQ 246_ TGQVG 251_ EKQSL 256_ KCEAA 261_ AGNPQ 266_ PSYRW 271_ FKDGK 276_ ELNRS 281_ RDIRI 286_ KYGNG 291_ RKNSR 296_ LQFNK 301_ VKVED 306_ AGEYV 311_ CEAEN 316_ ILGKD 321_ TVRGR 326_ LYVNS 331_ VSTTL 336_ SSWSG 341_ HARKC 346_ NETAK 351_ SYCVN 356_ GGVCY 361_ YIEGI 366_ NQLSC 371_ KCPNG 376_ FFGQR 381_ CLEKL 386_ PLRLY 391_ MPDPK 396_ QKAEE 401_ LYQKR 406_ VLTIT 411_ GICVA 416_ LLVVG 421_ IVCVV 426_ AYCKT 431_ KKQRK 436_ QMHNH 441_ LRQNM 446_ CPAHQ 451_ NRSLA 456_ NGPSH 461_ PRLDP 466_ EEIQM 471_ ADYIS 476_ KNVPA 481_ TDHVI 486_ RRETE 491_ TTFSG 496_ SHSCS 501_ PSHHC 506_ STATP 511_ TSSHR 516_ HESHT 521_ WSLER 526_ SESLT 531_ SDSQS 536_ GIMLS 541_ SVGTS 546_ KCNSP 551_ ACVEA 556_ RARRA 561_ AAYNL 566_ EERRR 571_ ATAPP 576_ YHDSV 581_ DSLRD 586_ SPHSE 591_ RYVSA 596_ LTTPA 601_ RLSPV 606_ DFHYS 611_ LATQV 616_ PTFEI 621_ TSPNS 626_ AHAVS 631_ LPPAA 636_ PISYR 641_ LAEQQ 646_ PLLRH 651_ PAPPG 656_ PGPGP 661_ GPGPG 666_ PGADM 671_ QRSYD 676_ SYYYP 681_ AAGPG 686_ PRRGT 691_ CALGG 696_ SLGSL 701_ PASPF 706_ RIPED 711_ DEYET 716_ TQECA 721_ PPPPP 726_ RPRAR 731_ GASRR 736_ TSAGP 741_ RRWRR 746_ SRLNG 751_ LAAQR 756_ ARAAR 761_ DSLSL 766_ SSGSG 771_ GGSAS 776_ ASDDD 781_ ADDAD 786_ GALAA 791_ ESTPF 796_ LGLRG 801_ AHDAL 806_ RSDSP 811_ PLCPA 816_ ADSRT 821_ YYSLD 826_ SHSTR 831_ ASSRH 836_ SRGPP 841_PRAKQ
1: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor