Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)
1_MVFRN 6_ VGRPP 11_ EEEDV 16_ EAAPE 21_ PGPSE 26_ LLCPR 31_ HRCAL 36_ DPKAL 41_ PPGLA 46_ LERTW 51_ GPAAG 56_ LEAQL 61_ AALGL 66_ GQPAG 71_ PGVKT 76_ VGGGC 81_ CPCPC 86_ PPQPP 91_ PPQPQ 96_ PPAAA 101_ PQAGE 106_ DPTET 111_ SDALL 116_ VLEGL 121_ ESEAE 126_ SLETN 131_ SCSEE 136_ ELSSP 141_ GRGGG 146_ GGGRL 151_ LLQPP 156_ GPELP 161_ PVPFP 166_ LQDLV 171_ PLGRL 176_ SRGEQ 181_ QQQQQ 186_ QQPPP 191_ PPPPP 196_ GPLRP 201_ LAGPS 206_ RKGSF 211_ KIRLS 216_ RLFRT 221_ KSCNG 226_ GSGGG 231_ DGTGK 236_ RPSGE 241_ LAASA 246_ ASLTD 251_ MGGSA 256_ GRELD 261_ AGRKP 266_ KLTRT 271_ QSAFS 276_ PVSFS 281_ PLFTG 286_ ETVSL 291_ VDVDI 296_ SQRGL 301_ TSPHP 306_ PTPPP 311_ PPRRS 316_ LSLLD 321_ DISGT 326_ LPTSV 331_ LVAPM 336_ GSSLQ 341_ SFPLP 346_ PPPPP 351_ HAPDA 356_ FPRIA 361_ PIRAA 366_ ESLHS 371_ QPPQH 376_ LQCPL 381_ YRPDS 386_ SSFAA 391_ SLREL 396_ EKCGW 401_ YWGPM 406_ NWEDA 411_ EMKLK 416_ GKPDG 421_ SFLVR 426_ DSSDP 431_ RYILS 436_ LSFRS 441_ QGITH 446_ HTRME 451_ HYRGT 456_ FSLWC 461_ HPKFE 466_ DRCQS 471_ VVEFI 476_ KRAIM 481_ HSKNG 486_ KFLYF 491_ LRSRV 496_ PGLPP 501_ TPVQL 506_ LYPVS 511_ RFSNV 516_ KSLQH 521_ LCRFR 526_ IRQLV 531_ RIDHI 536_ PDLPL 541_ PKPLI 546_ SYIRK 551_ FYYYD 556_ PQEEV 561_ YLSLK 566_ EAQLI 571_ SKQKQ 576_EVEPS
1: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1 (PubMed:16127460). Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (By similarity). The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development (By similarity). Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation (PubMed:16127460). Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA (PubMed:15677474)