Aquaporin-7 (AQP-7) (Aquaglyceroporin-7) (Aquaporin adipose) (AQPap) (Aquaporin-7-like)
1_MVQAS 6_ GHRRS 11_ TRGSK 16_ MVSWS 21_ VIAKI 26_ QEILQ 31_ RKMVR 36_ EFLAE 41_ FMSTY 46_ VMMVF 51_ GLGSV 56_ AHMVL 61_ NKKYG 66_ SYLGV 71_ NLGFG 76_ FGVTM 81_ GVHVA 86_ GRISG 91_ AHMNA 96_ AVTFA 101_ NCALG 106_ RVPWR 111_ KFPVY 116_ VLGQF 121_ LGSFL 126_ AAATI 131_ YSLFY 136_ TAILH 141_ FSGGQ 146_ LMVTG 151_ PVATA 156_ GIFAT 161_ YLPDH 166_ MTLWR 171_ GFLNE 176_ AWLTG 181_ MLQLC 186_ LFAIT 191_ DQENN 196_ PALPG 201_ TEALV 206_ IGILV 211_ VIIGV 216_ SLGMN 221_ TGYAI 226_ NPSRD 231_ LPPRI 236_ FTFIA 241_ GWGKQ 246_ VFSNG 251_ ENWWW 256_ VPVVA 261_ PLLGA 266_ YLGGI 271_ IYLVF 276_ IGSTI 281_ PREPL 286_ KLEDS 291_ VAYED 296_ HGITV 301_ LPKMG 306_ SHEPT 311_ ISPLT 316_ PVSVS 321_ PANRS 326_ SVHPA 331_ PPLHE 336_SMALE
1: Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:11952783, PubMed:30420639, PubMed:30423801, PubMed:36737436, PubMed:9405233). Could also be permeable to urea (PubMed:9405233). Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels (By similarity)