Gene name: SDHD

Uniprot entry:

O14521

Protein names:

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS) (CII-4) (QPs3) (Succinate dehydrogenase complex subunit D) (Succinate-ubiquinone oxidoreductase cytochrome b small subunit) (Succinate-ubiquinone reductase membrane anchor subunit)

Protein sequence:

1_MAVLW 6_ RLSAV 11_ CGALG 16_ GRALL 21_ LRTPV 26_ VRPAH 31_ ISAFL 36_ QDRPI 41_ PEWCG 46_ VQHIH 51_ LSPSH 56_ HSGSK 61_ AASLH 66_ WTSER 71_ VVSVL 76_ LLGLL 81_ PAAYL 86_ NPCSA 91_ MDYSL 96_ AAALT 101_ LHGHW 106_ GLGQV 111_ VTDYV 116_ HGDAL 121_ QKAAK 126_ AGLLA 131_ LSALT 136_ FAGLC 141_ YFNYH 146_ DVGIC 151_KAVAM

Protein annotations

Protein functions:

1: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:10482792, PubMed:9533030). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)