Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
1_MVTHS 6_ KFPAA 11_ GMSRP 16_ LDTSL 21_ RLKTF 26_ SSKSE 31_ YQLVV 36_ NAVRK 41_ LQESG 46_ FYWSA 51_ VTGGE 56_ ANLLL 61_ SAEPA 66_ GTFLI 71_ RDSSD 76_ QRHFF 81_ TLSVK 86_ TQSGT 91_ KNLRI 96_ QCEGG 101_ SFSLQ 106_ SDPRS 111_ TQPVP 116_ RFDCV 121_ LKLVH 126_ HYMPP 131_ PGAPS 136_ FPSPP 141_ TEPSS 146_ EVPEQ 151_ PSAQP 156_ LPGSP 161_ PRRAY 166_ YIYSG 171_ GEKIP 176_ LVLSR 181_ PLSSN 186_ VATLQ 191_ HLCRK 196_ TVNGH 201_ LDSYE 206_ KVTQL 211_ PGPIR 216_EFLDQ
1: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820)