Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
1_MKKIS 6_ LKTLR 11_ KSFNL 16_ NKSKE 21_ ETDFM 26_ VVQQP 31_ SLASD 36_ FGKDD 41_ SLFGS 46_ CYGKD 51_ MASCD 56_ INGED 61_ EKGGK 66_ NRSKS 71_ ESLMG 76_ TLKRR 81_ LSAKQ 86_ KSKGK 91_ AGTPS 96_ GSSAD 101_ EDTFS 106_ SSSAP 111_ IVFKD 116_ VRAQR 121_ PIRST 126_ SLRSH 131_ HYSPA 136_ PWPLR 141_ PTNSE 146_ ETCIK 151_ MEVRV 156_ KALVH 161_ SSSPS 166_ PALNG 171_ VRKDF 176_ HDLQS 181_ ETTCQ 186_ EQANS 191_ LKSSA 196_ SHNGD 201_ LHLHL 206_ DEHVP 211_ VVIGL 216_ MPQDY 221_ IQYTV 226_ PLDEG 231_ MYPLE 236_ GSRSY 241_ CLDSS 246_ SPMEV 251_ SAVPP 256_ QVGGR 261_ AFPED 266_ ESQVD 271_ QDLVV 276_ APEIF 281_ VDQSV 286_ NGLLI 291_ GTTGV 296_ MLQSP 301_ RAGHD 306_ DVPPL 311_ SPLLP 316_ PMQNN 321_ QIQRN 326_ FSGLT 331_ GTEAH 336_ VAESM 341_ RCHLN 346_ FDPNS 351_ APGVA 356_ RVYDS 361_ VQSSG 366_ PMVVT 371_ SLTEE 376_ LKKLA 381_ KQGWY 386_ WGPIT 391_ RWEAE 396_ GKLAN 401_ VPDGS 406_ FLVRD 411_ SSDDR 416_ YLLSL 421_ SFRSH 426_ GKTLH 431_ TRIEH 436_ SNGRF 441_ SFYEQ 446_ PDVEG 451_ HTSIV 456_ DLIEH 461_ SIRDS 466_ ENGAF 471_ CYSRS 476_ RLPGS 481_ ATYPV 486_ RLTNP 491_ VSRFM 496_ QVRSL 501_ QYLCR 506_ FVIRQ 511_ YTRID 516_ LIQKL 521_ PLPNK 526_MKDYL
1: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor