TRAF-type zinc finger domain-containing protein 1 (Protein FLN29)
1_MAEFL 6_ DDQET 11_ RLCDN 16_ CKKEI 21_ PVFNF 26_ TIHEI 31_ HCQRN 36_ IGMCP 41_ TCKEP 46_ FPKSD 51_ METHM 56_ AAEHC 61_ QVTCK 66_ CNKKL 71_ EKRLL 76_ KKHEE 81_ TECPL 86_ RLAVC 91_ QHCDL 96_ ELSIL 101_ KLKEH 106_ EDYCG 111_ ARTEL 116_ CGNCG 121_ RNVLV 126_ KDLKT 131_ HPEVC 136_ GREGE 141_ EKRNE 146_ VAIPP 151_ NAYDE 156_ SWGQD 161_ GIWIA 166_ SQLLR 171_ QIEAL 176_ DPPMR 181_ LPRRP 186_ LRAFE 191_ SDVFH 196_ NRTTN 201_ QRNIT 206_ AQVSI 211_ QNNLF 216_ EEQER 221_ QERNR 226_ GQQPP 231_ KEGGE 236_ ESANL 241_ DFMLA 246_ LSLQN 251_ EGQAS 256_ SVAEQ 261_ DFWRA 266_ VCEAD 271_ QSHGG 276_ PRSLS 281_ DIKGA 286_ ADEIM 291_ LPCEF 296_ CEELY 301_ PEELL 306_ IDHQT 311_ SCNPS 316_ RALPS 321_ LNTGS 326_ SSPRG 331_ VEEPD 336_ VIFQN 341_ FLQQA 346_ ASNQL 351_ DSLMG 356_ LSNSH 361_ PVEES 366_ IIIPC 371_ EFCGV 376_ QLEEE 381_ VLFHH 386_ QDQCD 391_ QRPAT 396_ ATNHV 401_ TEGIP 406_ RLDSQ 411_ PQETS 416_ PELPR 421_ RRVRH 426_ QGDLS 431_ SGYLD 436_ DTKQE 441_ TANGP 446_ TSCLP 451_ PSRPI 456_ NNMTA 461_ TYNQL 466_ SRSTS 471_ GPRPG 476_ CQPSS 481_ PCVPK 486_ LSNSD 491_ SQDIQ 496_ GRNRD 501_ SQNGA 506_ IAPGH 511_ VSVIR 516_ PPQNL 521_ YPENI 526_ VPSFS 531_ PGPSG 536_ RYGAS 541_ GRSEG 546_ GRNSR 551_ VTPAA 556_ ANYRS 561_ RTAKA 566_ KPSKQ 571_ QGAGD 576_AEEEE
1: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity)