Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20)
1_MEIPV 6_ PVQPS 11_ WLRRA 16_ SAPLP 21_ GLSAP 26_ GRLFD 31_ QRFGE 36_ GLLEA 41_ ELAAL 46_ CPTTL 51_ APYYL 56_ RAPSV 61_ ALPVA 66_ QVPTD 71_ PGHFS 76_ VLLDV 81_ KHFSP 86_ EEIAV 91_ KVVGE 96_ HVEVH 101_ ARHEE 106_ RPDEH 111_ GFVAR 116_ EFHRR 121_ YRLPP 126_ GVDPA 131_ AVTSA 136_ LSPEG 141_ VLSIQ 146_ AAPAS 151_AQAPP
1: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity