Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)
1_MASRV 6_ LSAYV 11_ SRLPA 16_ AFAPL 21_ PRVRM 26_ LAVAR 31_ PLSTA 36_ LCSAG 41_ TQTRL 46_ GTLQP 51_ ALVLA 56_ QVPGR 61_ VTQLC 66_ RQYSD 71_ MPPLT 76_ LEGIQ 81_ DRVLY 86_ VLKLY 91_ DKIDP 96_ EKLSV 101_ NSHFM 106_ KDLGL 111_ DSLDQ 116_ VEIIM 121_ AMEDE 126_ FGFEI 131_ PDIDA 136_ EKLMC 141_ PQEIV 146_ DYIAD 151_KKDVY
1: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) (PubMed:27626371). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:31664822). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity)