Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP)
1_MAPPA 6_ PGPAS 11_ GGSGE 16_ VDELF 21_ DVKNA 26_ FYIGS 31_ YQQCI 36_ NEAQR 41_ VKLSS 46_ PERDV 51_ ERDVF 56_ LYRAY 61_ LAQRK 66_ FGVVL 71_ DEIKP 76_ SSAPE 81_ LQAVR 86_ MFADY 91_ LAHES 96_ RRDSI 101_ VAELD 106_ REMSR 111_ SVDVT 116_ NTTFL 121_ LMAAS 126_ IYLHD 131_ QNPDA 136_ ALRAL 141_ HQGDS 146_ LECTA 151_ MTVQI 156_ LLKLD 161_ RLDLA 166_ RKELK 171_ RMQDL 176_ DEDAT 181_ LTQLA 186_ TAWVS 191_ LATGG 196_ EKLQD 201_ AYYIF 206_ QEMAD 211_ KCSPT 216_ LLLLN 221_ GQAAC 226_ HMAQG 231_ RWEAA 236_ EGLLQ 241_ EALDK 246_ DSGYP 251_ ETLVN 256_ LIVLS 261_ QHLGK 266_ PPEVT 271_ NRYLS 276_ QLKDA 281_ HRSHP 286_ FIKEY 291_ QAKEN 296_ DFDRL 301_VLQYA
1: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity)