DNA-binding protein RFXANK (Ankyrin repeat family A protein 1) (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein)
1_MELTQ 6_ PAEDL 11_ IQTQQ 16_ TPASE 21_ LGDPE 26_ DPGEE 31_ AADGS 36_ DTVVL 41_ SLFPC 46_ TPEPV 51_ NPEPD 56_ ASVSS 61_ PQAGS 66_ SLKHS 71_ TTLTN 76_ RQRGN 81_ EVSAL 86_ PATLD 91_ SLSIH 96_ QLAAQ 101_ GELDQ 106_ LKEHL 111_ RKGDN 116_ LVNKP 121_ DERGF 126_ TPLIW 131_ ASAFG 136_ EIETV 141_ RFLLE 146_ WGADP 151_ HILAK 156_ ERESA 161_ LSLAS 166_ TGGYT 171_ DIVGL 176_ LLERD 181_ VDINI 186_ YDWNG 191_ GTPLL 196_ YAVRG 201_ NHVKC 206_ VEALL 211_ ARGAD 216_ LTTEA 221_ DSGYT 226_ PMDLA 231_ VALGY 236_ RKVQQ 241_ VIENH 246_ ILKLF 251_QSNLV
1: Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:10072068, PubMed:10725724, PubMed:9806546). May also potentiate the activation of RAF1 (By similarity)
2: Isoform 2 is not involved in the positive regulation of MHC class II genes