Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 2) (NLI-interacting factor 2) (Protein OS-4) (Small C-terminal domain phosphatase 2) (Small CTD phosphatase 2) (SCP2)
1_MEHGS 6_ IITQA 11_ RREDA 16_ LVLTK 21_ QGLVS 26_ KSSPK 31_ KPRGR 36_ NIFKA 41_ LFCCF 46_ RAQHV 51_ GQSSS 56_ STELA 61_ AYKEE 66_ ANTIA 71_ KSDLL 76_ QCLQY 81_ QFYQI 86_ PGTCL 91_ LPEVT 96_ EEDQG 101_ RICVV 106_ IDLDE 111_ TLVHS 116_ SFKPI 121_ NNADF 126_ IVPIE 131_ IEGTT 136_ HQVYV 141_ LKRPY 146_ VDEFL 151_ RRMGE 156_ LFECV 161_ LFTAS 166_ LAKYA 171_ DPVTD 176_ LLDRC 181_ GVFRA 186_ RLFRE 191_ SCVFH 196_ QGCYV 201_ KDLSR 206_ LGRDL 211_ RKTLI 216_ LDNSP 221_ ASYIF 226_ HPENA 231_ VPVQS 236_ WFDDM 241_ ADTEL 246_ LNLIP 251_ IFEEL 256_ SGAED 261_ VYTSL 266_GQLRA
1: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas