G-protein coupled receptor 171 (G-protein coupled receptor H963)
1_MTNSS 6_ FFCPV 11_ YKDLE 16_ PFTYF 21_ FYLVF 26_ LVGII 31_ GSCFA 36_ TWAFI 41_ QKNTN 46_ HRCVS 51_ IYLIN 56_ LLTAD 61_ FLLTL 66_ ALPVK 71_ IVVDL 76_ GVAPW 81_ KLKIF 86_ HCQVT 91_ ACLIY 96_ INMYL 101_ SIIFL 106_ AFVSI 111_ DRCLQ 116_ LTHSC 121_ KIYRI 126_ QEPGF 131_ AKMIS 136_ TVVWL 141_ MVLLI 146_ MVPNM 151_ MIPIK 156_ DIKEK 161_ SNVGC 166_ MEFKK 171_ EFGRN 176_ WHLLT 181_ NFICV 186_ AIFLN 191_ FSAII 196_ LISNC 201_ LVIRQ 206_ LYRNK 211_ DNENY 216_ PNVKK 221_ ALINI 226_ LLVTT 231_ GYIIC 236_ FVPYH 241_ IVRIP 246_ YTLSQ 251_ TEVIT 256_ DCSTR 261_ ISLFK 266_ AKEAT 271_ LLLAV 276_ SNLCF 281_ DPILY 286_ YHLSK 291_ AFRSK 296_ VTETF 301_ ASPKE 306_ TKAQK 311_EKLRC
1: G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function (PubMed:34615877)