Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (E-NPP 3) (NPP3) (Phosphodiesterase I beta) (PD-Ibeta) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (CD antigen CD203c) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
1_MESTL 6_ TLATE 11_ QPVKK 16_ NTLKK 21_ YKIAC 26_ IVLLA 31_ LLVIM 36_ SLGLG 41_ LGLGL 46_ RKLEK 51_ QGSCR 56_ KKCFD 61_ ASFRG 66_ LENCR 71_ CDVAC 76_ KDRGD 81_ CCWDF 86_ EDTCV 91_ ESTRI 96_ WMCNK 101_ FRCGE 106_ TRLEA 111_ SLCSC 116_ SDDCL 121_ QRKDC 126_ CADYK 131_ SVCQG 136_ ETSWL 141_ EENCD 146_ TAQQS 151_ QCPEG 156_ FDLPP 161_ VILFS 166_ MDGFR 171_ AEYLY 176_ TWDTL 181_ MPNIN 186_ KLKTC 191_ GIHSK 196_ YMRAM 201_ YPTKT 206_ FPNHY 211_ TIVTG 216_ LYPES 221_ HGIID 226_ NNMYD 231_ VNLNK 236_ NFSLS 241_ SKEQN 246_ NPAWW 251_ HGQPM 256_ WLTAM 261_ YQGLK 266_ AATYF 271_ WPGSE 276_ VAING 281_ SFPSI 286_ YMPYN 291_ GSVPF 296_ EERIS 301_ TLLKW 306_ LDLPK 311_ AERPR 316_ FYTMY 321_ FEEPD 326_ SSGHA 331_ GGPVS 336_ ARVIK 341_ ALQVV 346_ DHAFG 351_ MLMEG 356_ LKQRN 361_ LHNCV 366_ NIILL 371_ ADHGM 376_ DQTYC 381_ NKMEY 386_ MTDYF 391_ PRINF 396_ FYMYE 401_ GPAPR 406_ IRAHN 411_ IPHDF 416_ FSFNS 421_ EEIVR 426_ NLSCR 431_ KPDQH 436_ FKPYL 441_ TPDLP 446_ KRLHY 451_ AKNVR 456_ IDKVH 461_ LFVDQ 466_ QWLAV 471_ RSKSN 476_ TNCGG 481_ GNHGY 486_ NNEFR 491_ SMEAI 496_ FLAHG 501_ PSFKE 506_ KTEVE 511_ PFENI 516_ EVYNL 521_ MCDLL 526_ RIQPA 531_ PNNGT 536_ HGSLN 541_ HLLKV 546_ PFYEP 551_ SHAEE 556_ VSKFS 561_ VCGFA 566_ NPLPT 571_ ESLDC 576_ FCPHL 581_ QNSTQ 586_ LEQVN 591_ QMLNL 596_ TQEEI 601_ TATVK 606_ VNLPF 611_ GRPRV 616_ LQKNV 621_ DHCLL 626_ YHREY 631_ VSGFG 636_ KAMRM 641_ PMWSS 646_ YTVPQ 651_ LGDTS 656_ PLPPT 661_ VPDCL 666_ RADVR 671_ VPPSE 676_ SQKCS 681_ FYLAD 686_ KNITH 691_ GFLYP 696_ PASNR 701_ TSDSQ 706_ YDALI 711_ TSNLV 716_ PMYEE 721_ FRKMW 726_ DYFHS 731_ VLLIK 736_ HATER 741_ NGVNV 746_ VSGPI 751_ FDYNY 756_ DGHFD 761_ APDEI 766_ TKHLA 771_ NTDVP 776_ IPTHY 781_ FVVLT 786_ SCKNK 791_ SHTPE 796_ NCPGW 801_ LDVLP 806_ FIIPH 811_ RPTNV 816_ ESCPE 821_ GKPEA 826_ LWVEE 831_ RFTAH 836_ IARVR 841_ DVELL 846_ TGLDF 851_ YQDKV 856_ QPVSE 861_ ILQLK 866_TYLPT
1: Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535, PubMed:9344668). Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation (By similarity). Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well (PubMed:12846830). In addition, displays an alkaline phosphodiesterase activity in vitro (PubMed:11342463)