Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
1_MAETK 6_ IIYHM 11_ DEEET 16_ PYLVK 21_ LPVAP 26_ ERVTL 31_ ADFKN 36_ VLSNR 41_ PVHAY 46_ KFFFK 51_ SMDQD 56_ FGVVK 61_ EEIFD 66_ DNAKL 71_ PCFNG 76_ RVVSW 81_ LVLAE 86_ GAHSD 91_ AGSQG 96_ TDSHT 101_ DLPPP 106_ LERTG 111_ GIGDS 116_ RPPSF 121_ HPNVA 126_ SSRDG 131_ MDNET 136_ GTESM 141_ VSHRR 146_ ERARR 151_ RNREE 156_ AARTN 161_ GHPRG 166_ DRRRD 171_ VGLPP 176_ DSAST 181_ ALSSE 186_ LESSS 191_ FVDSD 196_ EDGST 201_ SRLSS 206_ STEQS 211_ TSSRL 216_ IRKHK 221_ RRRRK 226_ QRLRQ 231_ ADRAS 236_ SFSSI 241_ TDSTM 246_ SLNIV 251_ TVTLN 256_ MERHH 261_ FLGIS 266_ IVGQS 271_ NDRGD 276_ GGIYI 281_ GSIMK 286_ GGAVA 291_ ADGRI 296_ EPGDM 301_ LLQVN 306_ DVNFE 311_ NMSND 316_ DAVRV 321_ LREIV 326_ SQTGP 331_ ISLTV 336_ AKCWD 341_ PTPRS 346_ YFTVP 351_ RADPV 356_ RPIDP 361_ AAWLS 366_ HTAAL 371_ TGALP 376_ RYGTS 381_ PCSSA 386_ VTRTS 391_ SSSLT 396_ SSVPG 401_ APQLE 406_ EAPLT 411_ VKSDM 416_ SAVVR 421_ VMQLP 426_ DSGLE 431_ IRDRM 436_ WLKIT 441_ IANAV 446_ IGADV 451_ VDWLY 456_ THVEG 461_ FKERR 466_ EARKY 471_ ASSLL 476_ KHGFL 481_ RHTVN 486_ KITFS 491_ EQCYY 496_ VFGDL 501_ CSNLA 506_ TLNLN 511_ SGSSG 516_ TSDQD 521_ TLAPL 526_ PHPAA 531_ PWPLG 536_ QGYPY 541_ QYPGP 546_ PPCFP 551_ PAYQD 556_ PGFSY 561_ GSGST 566_ GSQQS 571_ EGSKS 576_ SGSTR 581_ SSRRA 586_ PGREK 591_ ERRAA 596_ GAGGS 601_ GSESD 606_ HTAPS 611_ GVGSS 616_ WRERP 621_ AGQLS 626_ RGSSP 631_ RSQAS 636_ ATAPG 641_ LPPPH 646_ PTTKA 651_ YTVVG 656_ GPPGG 661_ PPVRE 666_ LAAVP 671_ PELTG 676_ SRQSF 681_ QKAMG 686_NPCEF
1: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ)