Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
1_MASCS 6_ FTRDQ 11_ ATRRL 16_ RGAAA 21_ AAAAA 26_ LAAVV 31_ TTPLL 36_ SSGTP 41_ TALIG 46_ TGSSC 51_ PGAMW 56_ LSTAT 61_ GSRSD 66_ SESEE 71_ EDLPV 76_ GEEVC 81_ KRGYL 86_ RKQKH 91_ GHRRY 96_ FVLKL 101_ ETADA 106_ PARLE 111_ YYENA 116_ RKFRH 121_ SVRAA 126_ AAAAA 131_ AAASG 136_ AAIPP 141_ LIPPR 146_ RVITL 151_ YQCFS 156_ VSQRA 161_ DARYR 166_ HLIAL 171_ FTQDE 176_ YFAMV 181_ AENES 186_ EQESW 191_ YLLLS 196_ RLILE 201_ SKRRR 206_ CGTLG 211_ AQPDG 216_ EPAAL 221_ AAAAA 226_ AEPPF 231_ YKDVW 236_ QVIVK 241_ PRGLG 246_ HRKEL 251_ SGVFR 256_ LCLTD 261_ EEVVF 266_ VRLNT 271_ EVASV 276_ VVQLL 281_ SIRRC 286_ GHSEQ 291_ YFFLE 296_ VGRST 301_ VIGPG 306_ ELWMQ 311_ VDDCV 316_ VAQNM 321_ HELFL 326_ EKMRA 331_ LCADE 336_ YRARC 341_ RSYSI 346_ SIGAH 351_ LLTLL 356_ SARRH 361_ LGLVP 366_ LEPGG 371_ WLRRS 376_ RFEQF 381_ CHLRA 386_ IGDGE 391_ DEMLF 396_ TRRFV 401_ TPSEP 406_ VAHSR 411_ RGRLH 416_ LPRGR 421_ RSRRA 426_ VSVPA 431_ SFFRR 436_ LAPSP 441_ ARPRH 446_ PAEAP 451_ NNGAR 456_ LSSEV 461_ SGSGS 466_ GNFGE 471_ EGNPQ 476_ GKEDQ 481_ EGSGG 486_ DYMPM 491_ NNWGS 496_ GNGRG 501_ SGGGQ 506_ GSNGQ 511_ GSSSH 516_ SSGGN 521_ QCSGE 526_ GQGSR 531_ GGQGS 536_ NGQGS 541_ GGNQC 546_ SRDGQ 551_ GTAGG 556_ HGSGG 561_ GQRPG 566_ GGHGS 571_ GGGQG 576_ PGDGH 581_ GSGGG 586_ KNSGG 591_ GKGSG 596_ SGKGS 601_ DGDGE 606_ RGKSL 611_ KKRSY 616_ FGKLT 621_ QSKQQ 626_ QMPPP 631_ PPPPP 636_ PPPPA 641_ GGTGG 646_ KGKSG 651_ GRFRL 656_ YFCVD 661_ RGATK 666_ ECKEA 671_ KEVKD 676_ AEIPE 681_ GAARG 686_ PHRAR 691_ AFDED 696_ EDDPY 701_ VPMRP 706_ GVATP 711_ LVSSS 716_ DYMPM 721_ APQNV 726_ SASKK 731_ RHSRS 736_ PFEDS 741_ RGYMM 746_ MFPRV 751_ SPPPA 756_ PSPPK 761_ APDTN 766_ KEDDS 771_ KDNDS 776_ ESDYM 781_ FMAPG 786_ AGAIP 791_ KNPRN 796_ PQGGS 801_ SSKSW 806_ SSYFS 811_ LPNPF 816_ RSSPL 821_ GQNDN 826_ SEYVP 831_ MLPGK 836_ FLGRG 841_ LDKEV 846_ SYNWD 851_ PKDAA 856_ SKPSG 861_ EGSFS 866_ KPGDG 871_ GSPSK 876_ PSDHE 881_ PPKNK 886_ AKRPN 891_ RLSFI 896_ TKGYK 901_ IKPKP 906_ QKPTH 911_ EQREA 916_ DSSSD 921_ YVNMD 926_ FTKRE 931_ SNTPA 936_ PSTQG 941_ LPDSW 946_ GIIAE 951_ PRQSA 956_ FSNYV 961_ NVEFG 966_ VPFPN 971_ PANDL 976_ SDLLR 981_ AIPRA 986_ NPLSL 991_ DSARW 996_ PLPPL 1001_ PLSAT 1006_ GSNAI 1011_ EEEGD 1016_ YIEVI 1021_ FNSAM 1026_ TPAMA 1031_ LADSA 1036_ IRYDA 1041_ ETGRI 1046_ YVVDP 1051_ FSECC 1056_ MDISL 1061_ SPSRC 1066_ SEPPP 1071_ VARLL 1076_ QEEEQ 1081_ ERRRP 1086_ QSRSQ 1091_ SFFAA 1096_ ARAAV 1101_ SAFPT 1106_ DSLER 1111_ DLSPS 1116_ SAPAV 1121_ ASAAE 1126_ PTLAL 1131_ SQVVA 1136_ AASAL 1141_ AAAPG 1146_ IGAAA 1151_ AAAGF 1156_ DSASA 1161_ RWFQP 1166_ VANAA 1171_ DAEAV 1176_ RGAQD 1181_ VAGGS 1186_ NPGAH 1191_ NPSAN 1196_ LARGD 1201_ NQAGG 1206_ AAAAA 1211_ AAPEP 1216_ PPRSR 1221_ RVPRP 1226_ PERED 1231_ SDNDD 1236_ DTHVR 1241_ MDFAR 1246_ RDNQF 1251_DSPKR
1: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2