Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)
1_MVLLR 6_ VLILL 11_ LSWAA 16_ GMGGQ 21_ YGNPL 26_ NKYIR 31_ HYEGL 36_ SYNVD 41_ SLHQK 46_ HQRAK 51_ RAVSH 56_ EDQFL 61_ RLDFH 66_ AHGRH 71_ FNLRM 76_ KRDTS 81_ LFSDE 86_ FKVET 91_ SNKVL 96_ DYDTS 101_ HIYTG 106_ HIYGE 111_ EGSFS 116_ HGSVI 121_ DGRFE 126_ GFIQT 131_ RGGTF 136_ YVEPA 141_ ERYIK 146_ DRTLP 151_ FHSVI 156_ YHEDD 161_ INYPH 166_ KYGPQ 171_ GGCAD 176_ HSVFE 181_ RMRKY 186_ QMTGV 191_ EEVTQ 196_ IPQEE 201_ HAANG 206_ PELLR 211_ KKRTT 216_ SAEKN 221_ TCQLY 226_ IQTDH 231_ LFFKY 236_ YGTRE 241_ AVIAQ 246_ ISSHV 251_ KAIDT 256_ IYQTT 261_ DFSGI 266_ RNISF 271_ MVKRI 276_ RINTT 281_ ADEKD 286_ PTNPF 291_ RFPNI 296_ GVEKF 301_ LELNS 306_ EQNHD 311_ DYCLA 316_ YVFTD 321_ RDFDD 326_ GVLGL 331_ AWVGA 336_ PSGSS 341_ GGICE 346_ KSKLY 351_ SDGKK 356_ KSLNT 361_ GIITV 366_ QNYGS 371_ HVPPK 376_ VSHIT 381_ FAHEV 386_ GHNFG 391_ SPHDS 396_ GTECT 401_ PGESK 406_ NLGQK 411_ ENGNY 416_ IMYAR 421_ ATSGD 426_ KLNNN 431_ KFSLC 436_ SIRNI 441_ SQVLE 446_ KKRNN 451_ CFVES 456_ GQPIC 461_ GNGMV 466_ EQGEE 471_ CDCGY 476_ SDQCK 481_ DECCF 486_ DANQP 491_ EGRKC 496_ KLKPG 501_ KQCSP 506_ SQGPC 511_ CTAQC 516_ AFKSK 521_ SEKCR 526_ DDSDC 531_ AREGI 536_ CNGFT 541_ ALCPA 546_ SDPKP 551_ NFTDC 556_ NRHTQ 561_ VCING 566_ QCAGS 571_ ICEKY 576_ GLEEC 581_ TCASS 586_ DGKDD 591_ KELCH 596_ VCCMK 601_ KMDPS 606_ TCAST 611_ GSVQW 616_ SRHFS 621_ GRTIT 626_ LQPGS 631_ PCNDF 636_ RGYCD 641_ VFMRC 646_ RLVDA 651_ DGPLA 656_ RLKKA 661_ IFSPE 666_ LYENI 671_ AEWIV 676_ AHWWA 681_ VLLMG 686_ IALIM 691_ LMAGF 696_ IKICS 701_ VHTPS 706_ SNPKL 711_ PPPKP 716_ LPGTL 721_ KRRRP 726_ PQPIQ 731_ QPQRQ 736_ RPRES 741_YQMGH
1: Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis (PubMed:11786905, PubMed:12475894, PubMed:20592283, PubMed:24990881, PubMed:26686862, PubMed:28600292, PubMed:31792032). Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity (PubMed:26686862, PubMed:28600292, PubMed:31792032, PubMed:34739841, PubMed:37516108). Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:11786905, PubMed:26686862, PubMed:29224781, PubMed:34739841). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Also controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Required for the development of type 1 transitional B cells into marginal zone B cells, probably by cleaving Notch (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (PubMed:24990881). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). Regulates leukocyte transmigration as a sheddase for the adherens junction protein VE-cadherin/CDH5 in endothelial cells (PubMed:28600292)
2: (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores