Prostaglandin E synthase (EC 5.3.99.3) (Glutathione peroxidase PTGES) (EC 1.11.1.-) (Glutathione transferase PTGES) (EC 2.5.1.18) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gene 12 protein)
1_MPAHS 6_ LVMSS 11_ PALPA 16_ FLLCS 21_ TLLVI 26_ KMYVV 31_ AIITG 36_ QVRLR 41_ KKAFA 46_ NPEDA 51_ LRHGG 56_ PQYCR 61_ SDPDV 66_ ERCLR 71_ AHRND 76_ METIY 81_ PFLFL 86_ GFVYS 91_ FLGPN 96_ PFVAW 101_ MHFLV 106_ FLVGR 111_ VAHTV 116_ AYLGK 121_ LRAPI 126_ RSVTY 131_ TLAQL 136_ PCASM 141_ ALQIL 146_WEAAR
1: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10377395, PubMed:10869354, PubMed:12244105, PubMed:12460774, PubMed:12672824, PubMed:18682561). Plays a key role in inflammation response, fever and pain (By similarity). Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824)