Apoptotic protease-activating factor 1 (APAF-1)
1_MDAKA 6_ RNCLL 11_ QHREA 16_ LEKDI 21_ KTSYI 26_ MDHMI 31_ SDGFL 36_ TISEE 41_ EKVRN 46_ EPTQQ 51_ QRAAM 56_ LIKMI 61_ LKKDN 66_ DSYVS 71_ FYNAL 76_ LHEGY 81_ KDLAA 86_ LLHDG 91_ IPVVS 96_ SSSGK 101_ DSVSG 106_ ITSYV 111_ RTVLC 116_ EGGVP 121_ QRPVV 126_ FVTRK 131_ KLVNA 136_ IQQKL 141_ SKLKG 146_ EPGWV 151_ TIHGM 156_ AGCGK 161_ SVLAA 166_ EAVRD 171_ HSLLE 176_ GCFPG 181_ GVHWV 186_ SVGKQ 191_ DKSGL 196_ LMKLQ 201_ NLCTR 206_ LDQDE 211_ SFSQR 216_ LPLNI 221_ EEAKD 226_ RLRIL 231_ MLRKH 236_ PRSLL 241_ ILDDV 246_ WDSWV 251_ LKAFD 256_ SQCQI 261_ LLTTR 266_ DKSVT 271_ DSVMG 276_ PKYVV 281_ PVESS 286_ LGKEK 291_ GLEIL 296_ SLFVN 301_ MKKAD 306_ LPEQA 311_ HSIIK 316_ ECKGS 321_ PLVVS 326_ LIGAL 331_ LRDFP 336_ NRWEY 341_ YLKQL 346_ QNKQF 351_ KRIRK 356_ SSSYD 361_ YEALD 366_ EAMSI 371_ SVEML 376_ REDIK 381_ DYYTD 386_ LSILQ 391_ KDVKV 396_ PTKVL 401_ CILWD 406_ METEE 411_ VEDIL 416_ QEFVN 421_ KSLLF 426_ CDRNG 431_ KSFRY 436_ YLHDL 441_ QVDFL 446_ TEKNC 451_ SQLQD 456_ LHKKI 461_ ITQFQ 466_ RYHQP 471_ HTLSP 476_ DQEDC 481_ MYWYN 486_ FLAYH 491_ MASAK 496_ MHKEL 501_ CALMF 506_ SLDWI 511_ KAKTE 516_ LVGPA 521_ HLIHE 526_ FVEYR 531_ HILDE 536_ KDCAV 541_ SENFQ 546_ EFLSL 551_ NGHLL 556_ GRQPF 561_ PNIVQ 566_ LGLCE 571_ PETSE 576_ VYQQA 581_ KLQAK 586_ QEVDN 591_ GMLYL 596_ EWINK 601_ KNITN 606_ LSRLV 611_ VRPHT 616_ DAVYH 621_ ACFSE 626_ DGQRI 631_ ASCGA 636_ DKTLQ 641_ VFKAE 646_ TGEKL 651_ LEIKA 656_ HEDEV 661_ LCCAF 666_ STDDR 671_ FIATC 676_ SVDKK 681_ VKIWN 686_ SMTGE 691_ LVHTY 696_ DEHSE 701_ QVNCC 706_ HFTNS 711_ SHHLL 716_ LATGS 721_ SDCFL 726_ KLWDL 731_ NQKEC 736_ RNTMF 741_ GHTNS 746_ VNHCR 751_ FSPDD 756_ KLLAS 761_ CSADG 766_ TLKLW 771_ DATSA 776_ NERKS 781_ INVKQ 786_ FFLNL 791_ EDPQE 796_ DMEVI 801_ VKCCS 806_ WSADG 811_ ARIMV 816_ AAKNK 821_ IFLFD 826_ IHTSG 831_ LLGEI 836_ HTGHH 841_ STIQY 846_ CDFSP 851_ QNHLA 856_ VVALS 861_ QYCVE 866_ LWNTD 871_ SRSKV 876_ ADCRG 881_ HLSWV 886_ HGVMF 891_ SPDGS 896_ SFLTS 901_ SDDQT 906_ IRLWE 911_ TKKVC 916_ KNSAV 921_ MLKQE 926_ VDVVF 931_ QENEV 936_ MVLAV 941_ DHIRR 946_ LQLIN 951_ GRTGQ 956_ IDYLT 961_ EAQVS 966_ CCCLS 971_ PHLQY 976_ IAFGD 981_ ENGAI 986_ EILEL 991_ VNNRI 996_ FQSRF 1001_ QHKKT 1006_ VWHIQ 1011_ FTADE 1016_ KTLIS 1021_ SSDDA 1026_ EIQVW 1031_ NWQLD 1036_ KCIFL 1041_ RGHQE 1046_ TVKDF 1051_ RLLKN 1056_ SRLLS 1061_ WSFDG 1066_ TVKVW 1071_ NIITG 1076_ NKEKD 1081_ FVCHQ 1086_ GTVLS 1091_ CDISH 1096_ DATKF 1101_ SSTSA 1106_ DKTAK 1111_ IWSFD 1116_ LLLPL 1121_ HELRG 1126_ HNGCV 1131_ RCSAF 1136_ SVDST 1141_ LLATG 1146_ DDNGE 1151_ IRIWN 1156_ VSNGE 1161_ LLHLC 1166_ APLSE 1171_ EGAAT 1176_ HGGWV 1181_ TDLCF 1186_ SPDGK 1191_ MLISA 1196_ GGYIK 1201_ WWNVV 1206_ TGESS 1211_ QTFYT 1216_ NGTNL 1221_ KKIHV 1226_ SPDFK 1231_ TYVTV 1236_ DNLGI 1241_LYILQ
1: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis