Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog)
1_MDLVG 6_ VASPE 11_ PGTAA 16_ AWGPS 21_ KCPWA 26_ IPQNT 31_ ISCSL 36_ ADVMS 41_ EQLAK 46_ ELQLE 51_ EEAAV 56_ FPEVA 61_ VAEGP 66_ FITGE 71_ NIDTS 76_ SDLML 81_ AQMLQ 86_ MEYDR 91_ EYDAQ 96_ LRREE 101_ KKFNG 106_ DSKVS 111_ ISFEN 116_ YRKVH 121_ PYEDS 126_ DSSED 131_ EVDWQ 136_ DTRDD 141_ PYRPA 146_ KPVPT 151_ PKKGF 156_ IGKGK 161_ DITTK 166_ HDEVV 171_ CGRKN 176_ TARME 181_ NFAPE 186_ FQVGD 191_ GIGMD 196_ LKLSN 201_ HVFNA 206_ LKQHA 211_ YSEER 216_ RSARL 221_ HEKKE 226_ HSTAE 231_ KAVDP 236_ KTRLL 241_ MYKMV 246_ NSGML 251_ ETITG 256_ CISTG 261_ KESVV 266_ FHAYG 271_ GSMED 276_ EKEDS 281_ KVIPT 286_ ECAIK 291_ VFKTT 296_ LNEFK 301_ NRDKY 306_ IKDDF 311_ RFKDR 316_ FSKLN 321_ PRKII 326_ RMWAE 331_ KEMHN 336_ LARMQ 341_ RAGIP 346_ CPTVV 351_ LLKKH 356_ ILVMS 361_ FIGHD 366_ QVPAP 371_ KLKEV 376_ KLNSE 381_ EMKEA 386_ YYQTL 391_ HLMRQ 396_ LYHEC 401_ TLVHA 406_ DLSEY 411_ NMLWH 416_ AGKVW 421_ LIDVS 426_ QSVEP 431_ THPHG 436_ LEFLF 441_ RDCRN 446_ VSQFF 451_ QKGGV 456_ KEALS 461_ ERELF 466_ NAVSG 471_ LNITA 476_ DNEAD 481_ FLAEI 486_ EALEK 491_ MNEDH 496_ VQKNG 501_ RKAAS 506_ FLKDD 511_GDPPL
1: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843)