Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
1_MSADA 6_ AAGAP 11_ LPRLC 16_ CLEKG 21_ PNGYG 26_ FHLHG 31_ EKGKL 36_ GQYIR 41_ LVEPG 46_ SPAEK 51_ AGLLA 56_ GDRLV 61_ EVNGE 66_ NVEKE 71_ THQQV 76_ VSRIR 81_ AALNA 86_ VRLLV 91_ VDPET 96_ DEQLQ 101_ KLGVQ 106_ VREEL 111_ LRAQE 116_ APGQA 121_ EPPAA 126_ AEVQG 131_ AGNEN 136_ EPREA 141_ DKSHP 146_ EQREL 151_ RPRLC 156_ TMKKG 161_ PSGYG 166_ FNLHS 171_ DKSKP 176_ GQFIR 181_ SVDPD 186_ SPAEA 191_ SGLRA 196_ QDRIV 201_ EVNGV 206_ CMEGK 211_ QHGDV 216_ VSAIR 221_ AGGDE 226_ TKLLV 231_ VDRET 236_ DEFFK 241_ KCRVI 246_ PSQEH 251_ LNGPL 256_ PVPFT 261_ NGEIQ 266_ KENSR 271_ EALAE 276_ AALES 281_ PRPAL 286_ VRSAS 291_ SDTSE 296_ ELNSQ 301_ DSPPK 306_ QDSTA 311_ PSSTS 316_ SSDPI 321_ LDFNI 326_ SLAMA 331_ KERAH 336_ QKRSS 341_ KRAPQ 346_ MDWSK 351_KNELF
1: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa