Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2)
1_MPRAP 6_ RCRAV 11_ RSLLR 16_ SHYRE 21_ VLPLA 26_ TFVRR 31_ LGPQG 36_ WRLVQ 41_ RGDPA 46_ AFRAL 51_ VAQCL 56_ VCVPW 61_ DARPP 66_ PAAPS 71_ FRQVS 76_ CLKEL 81_ VARVL 86_ QRLCE 91_ RGAKN 96_ VLAFG 101_ FALLD 106_ GARGG 111_ PPEAF 116_ TTSVR 121_ SYLPN 126_ TVTDA 131_ LRGSG 136_ AWGLL 141_ LRRVG 146_ DDVLV 151_ HLLAR 156_ CALFV 161_ LVAPS 166_ CAYQV 171_ CGPPL 176_ YQLGA 181_ ATQAR 186_ PPPHA 191_ SGPRR 196_ RLGCE 201_ RAWNH 206_ SVREA 211_ GVPLG 216_ LPAPG 221_ ARRRG 226_ GSASR 231_ SLPLP 236_ KRPRR 241_ GAAPE 246_ PERTP 251_ VGQGS 256_ WAHPG 261_ RTRGP 266_ SDRGF 271_ CVVSP 276_ ARPAE 281_ EATSL 286_ EGALS 291_ GTRHS 296_ HPSVG 301_ RQHHA 306_ GPPST 311_ SRPPR 316_ PWDTP 321_ CPPVY 326_ AETKH 331_ FLYSS 336_ GDKEQ 341_ LRPSF 346_ LLSSL 351_ RPSLT 356_ GARRL 361_ VETIF 366_ LGSRP 371_ WMPGT 376_ PRRLP 381_ RLPQR 386_ YWQMR 391_ PLFLE 396_ LLGNH 401_ AQCPY 406_ GVLLK 411_ THCPL 416_ RAAVT 421_ PAAGV 426_ CAREK 431_ PQGSV 436_ AAPEE 441_ EDTDP 446_ RRLVQ 451_ LLRQH 456_ SSPWQ 461_ VYGFV 466_ RACLR 471_ RLVPP 476_ GLWGS 481_ RHNER 486_ RFLRN 491_ TKKFI 496_ SLGKH 501_ AKLSL 506_ QELTW 511_ KMSVR 516_ DCAWL 521_ RRSPG 526_ VGCVP 531_ AAEHR 536_ LREEI 541_ LAKFL 546_ HWLMS 551_ VYVVE 556_ LLRSF 561_ FYVTE 566_ TTFQK 571_ NRLFF 576_ YRKSV 581_ WSKLQ 586_ SIGIR 591_ QHLKR 596_ VQLRE 601_ LSEAE 606_ VRQHR 611_ EARPA 616_ LLTSR 621_ LRFIP 626_ KPDGL 631_ RPIVN 636_ MDYVV 641_ GARTF 646_ RREKR 651_ AERLT 656_ SRVKA 661_ LFSVL 666_ NYERA 671_ RRPGL 676_ LGASV 681_ LGLDD 686_ IHRAW 691_ RTFVL 696_ RVRAQ 701_ DPPPE 706_ LYFVK 711_ VDVTG 716_ AYDTI 721_ PQDRL 726_ TEVIA 731_ SIIKP 736_ QNTYC 741_ VRRYA 746_ VVQKA 751_ AHGHV 756_ RKAFK 761_ SHVST 766_ LTDLQ 771_ PYMRQ 776_ FVAHL 781_ QETSP 786_ LRDAV 791_ VIEQS 796_ SSLNE 801_ ASSGL 806_ FDVFL 811_ RFMCH 816_ HAVRI 821_ RGKSY 826_ VQCQG 831_ IPQGS 836_ ILSTL 841_ LCSLC 846_ YGDME 851_ NKLFA 856_ GIRRD 861_ GLLLR 866_ LVDDF 871_ LLVTP 876_ HLTHA 881_ KTFLR 886_ TLVRG 891_ VPEYG 896_ CVVNL 901_ RKTVV 906_ NFPVE 911_ DEALG 916_ GTAFV 921_ QMPAH 926_ GLFPW 931_ CGLLL 936_ DTRTL 941_ EVQSD 946_ YSSYA 951_ RTSIR 956_ ASLTF 961_ NRGFK 966_ AGRNM 971_ RRKLF 976_ GVLRL 981_ KCHSL 986_ FLDLQ 991_ VNSLQ 996_ TVCTN 1001_ IYKIL 1006_ LLQAY 1011_ RFHAC 1016_ VLQLP 1021_ FHQQV 1026_ WKNPT 1031_ FFLRV 1036_ ISDTA 1041_ SLCYS 1046_ ILKAK 1051_ NAGMS 1056_ LGAKG 1061_ AAGPL 1066_ PSEAV 1071_ QWLCH 1076_ QAFLL 1081_ KLTRH 1086_ RVTYV 1091_ PLLGS 1096_ LRTAQ 1101_ TQLSR 1106_ KLPGT 1111_ TLTAL 1116_ EAAAN 1121_ PALPS 1126_DFKTI
1: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis