17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.239) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6)
1_MWLYL 6_ AAFVG 11_ LYYLL 16_ HWYRE 21_ RQVVS 26_ HLQDK 31_ YVFIT 36_ GCDSG 41_ FGNLL 46_ ARQLD 51_ ARGLR 56_ VLAAC 61_ LTEKG 66_ AEQLR 71_ GQTSD 76_ RLETV 81_ TLDVT 86_ KMESI 91_ AAATQ 96_ WVKEH 101_ VGDRG 106_ LWGLV 111_ NNAGI 116_ LTPIT 121_ LCEWL 126_ NTEDS 131_ MNMLK 136_ VNLIG 141_ VIQVT 146_ LSMLP 151_ LVRRA 156_ RGRIV 161_ NVSSI 166_ LGRVA 171_ FFVGG 176_ YCVSK 181_ YGVEA 186_ FSDIL 191_ RREIQ 196_ HFGVK 201_ ISIVE 206_ PGYFR 211_ TGMTN 216_ MTQSL 221_ ERMKQ 226_ SWKEA 231_ PKHIK 236_ ETYGQ 241_ QYFDA 246_ LYNIM 251_ KEGLL 256_ NCSTN 261_ LNLVT 266_ DCMEH 271_ ALTSV 276_ HPRTR 281_ YSAGW 286_ DAKFF 291_ FIPLS 296_ YLPTS 301_ LADYI 306_ LTRSW 311_PKPAQ
1: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids