Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)
1_MEQRG 6_ QNAPA 11_ ASGAR 16_ KRHGP 21_ GPREA 26_ RGARP 31_ GPRVP 36_ KTLVL 41_ VVAAV 46_ LLLVS 51_ AESAL 56_ ITQQD 61_ LAPQQ 66_ RAAPQ 71_ QKRSS 76_ PSEGL 81_ CPPGH 86_ HISED 91_ GRDCI 96_ SCKYG 101_ QDYST 106_ HWNDL 111_ LFCLR 116_ CTRCD 121_ SGEVE 126_ LSPCT 131_ TTRNT 136_ VCQCE 141_ EGTFR 146_ EEDSP 151_ EMCRK 156_ CRTGC 161_ PRGMV 166_ KVGDC 171_ TPWSD 176_ IECVH 181_ KESGT 186_ KHSGE 191_ VPAVE 196_ ETVTS 201_ SPGTP 206_ ASPCS 211_ LSGII 216_ IGVTV 221_ AAVVL 226_ IVAVF 231_ VCKSL 236_ LWKKV 241_ LPYLK 246_ GICSG 251_ GGGDP 256_ ERVDR 261_ SSQRP 266_ GAEDN 271_ VLNEI 276_ VSILQ 281_ PTQVP 286_ EQEME 291_ VQEPA 296_ EPTGV 301_ NMLSP 306_ GESEH 311_ LLEPA 316_ EAERS 321_ QRRRL 326_ LVPAN 331_ EGDPT 336_ ETLRQ 341_ CFDDF 346_ ADLVP 351_ FDSWE 356_ PLMRK 361_ LGLMD 366_ NEIKV 371_ AKAEA 376_ AGHRD 381_ TLYTM 386_ LIKWV 391_ NKTGR 396_ DASVH 401_ TLLDA 406_ LETLG 411_ ERLAK 416_ QKIED 421_ HLLSS 426_ GKFMY 431_LEGNA
1: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis