Gamma-aminobutyric acid receptor subunit delta (GABA(A) receptor subunit delta)
1_MDAPA 6_ RLLAP 11_ LLLLC 16_ AQQLR 21_ GTRAM 26_ NDIGD 31_ YVGSN 36_ LEISW 41_ LPNLD 46_ GLIAG 51_ YARNF 56_ RPGIG 61_ GPPVN 66_ VALAL 71_ EVASI 76_ DHISE 81_ ANMEY 86_ TMTVF 91_ LHQSW 96_ RDSRL 101_ SYNHT 106_ NETLG 111_ LDSRF 116_ VDKLW 121_ LPDTF 126_ IVNAK 131_ SAWFH 136_ DVTVE 141_ NKLIR 146_ LQPDG 151_ VILYS 156_ IRITS 161_ TVACD 166_ MDLAK 171_ YPMDE 176_ QECML 181_ DLESY 186_ GYSSE 191_ DIVYY 196_ WSESQ 201_ EHIHG 206_ LDKLQ 211_ LAQFT 216_ ITSYR 221_ FTTEL 226_ MNFKS 231_ AGQFP 236_ RLSLH 241_ FHLRR 246_ NRGVY 251_ IIQSY 256_ MPSVL 261_ LVAMS 266_ WVSFW 271_ ISQAA 276_ VPARV 281_ SLGIT 286_ TVLTM 291_ TTLMV 296_ SARSS 301_ LPRAS 306_ AIKAL 311_ DVYFW 316_ ICYVF 321_ VFAAL 326_ VEYAF 331_ AHFNA 336_ DYRKK 341_ QKAKV 346_ KVSRP 351_ RAEMD 356_ VRNAI 361_ VLFSL 366_ SAAGV 371_ TQELA 376_ ISRRQ 381_ RRVPG 386_ NLMGS 391_ YRSVG 396_ VETGE 401_ TKKEG 406_ AARSG 411_ GQGGI 416_ RARLR 421_ PIDAD 426_ TIDIY 431_ ARAVF 436_ PAAFA 441_ AVNVI 446_YWAAY
1: Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:35355020). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:35355020). GABAARs containing delta/GABRD subunits are predominantly located in extrasynaptic or perisynaptic positions on hippocampus and cerebellar granule cells, and contribute to the tonic GABAergic inhibition (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:35355020)