Homeobox protein Meis2 (Meis1-related protein 1)
1_MAQRY 6_ DELPH 11_ YGGMD 16_ GVGVP 21_ ASMYG 26_ DPHAP 31_ RPIPP 36_ VHHLN 41_ HGPPL 46_ HATQH 51_ YGAHA 56_ PHPNV 61_ MPASM 66_ GSAVN 71_ DALKR 76_ DKDAI 81_ YGHPL 86_ FPLLA 91_ LVFEK 96_ CELAT 101_ CTPRE 106_ PGVAG 111_ GDVCS 116_ SDSFN 121_ EDIAV 126_ FAKQV 131_ RAEKP 136_ LFSSN 141_ PELDN 146_ LMIQA 151_ IQVLR 156_ FHLLE 161_ LEKVH 166_ ELCDN 171_ FCHRY 176_ ISCLK 181_ GKMPI 186_ DLVID 191_ ERDGS 196_ SKSDH 201_ EELSG 206_ SSTNL 211_ ADHNP 216_ SSWRD 221_ HDDAT 226_ STHSA 231_ GTPGP 236_ SSGGH 241_ ASQSG 246_ DNSSE 251_ QGDGL 256_ DNSVA 261_ SPGTG 266_ DDDDP 271_ DKDKK 276_ RQKKR 281_ GIFPK 286_ VATNI 291_ MRAWL 296_ FQHLT 301_ HPYPS 306_ EEQKK 311_ QLAQD 316_ TGLTI 321_ LQVNN 326_ WFINA 331_ RRRIV 336_ QPMID 341_ QSNRA 346_ GFLLD 351_ PSVSQ 356_ GAAYS 361_ PEGQP 366_ MGSFV 371_ LDGQQ 376_ HMGIR 381_ PAGLQ 386_ SMPGD 391_ YVSQG 396_ GPMGM 401_ SMAQP 406_ SYTPP 411_ QMTPH 416_ PTQLR 421_ HGPPM 426_ HSYLP 431_ SHPHH 436_ PAMMM 441_ HGGPP 446_ THPGM 451_ TMSAQ 456_ SPTML 461_ NSVDP 466_ NVGGQ 471_VMDIH
1: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription