Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5)
1_MCDQT 6_ FLVNV 11_ FGSCD 16_ KCFKQ 21_ RALRP 26_ VFKKS 31_ QQLSY 36_ CSTCA 41_ EIMAT 46_ EGLHE 51_ NETLA 56_ SLKSE 61_ AESLK 66_ GKLEE 71_ ERAKL 76_ HDVEL 81_ HQVAE 86_ RVEAL 91_ GQFVM 96_ KTRRT 101_ LKGHG 106_ NKVLC 111_ MDWCK 116_ DKRRI 121_ VSSSQ 126_ DGKVI 131_ VWDSF 136_ TTNKE 141_ HAVTM 146_ PCTWV 151_ MACAY 156_ APSGC 161_ AIACG 166_ GLDNK 171_ CSVYP 176_ LTFDK 181_ NENMA 186_ AKKKS 191_ VAMHT 196_ NYLSA 201_ CSFTN 206_ SDMQI 211_ LTASG 216_ DGTCA 221_ LWDVE 226_ SGQLL 231_ QSFHG 236_ HGADV 241_ LCLDL 246_ APSET 251_ GNTFV 256_ SGGCD 261_ KKAMV 266_ WDMRS 271_ GQCVQ 276_ AFETH 281_ ESDIN 286_ SVRYY 291_ PSGDA 296_ FASGS 301_ DDATC 306_ RLYDL 311_ RADRE 316_ VAIYS 321_ KESII 326_ FGASS 331_ VDFSL 336_ SGRLL 341_ FAGYN 346_ DYTIN 351_ VWDVL 356_ KGSRV 361_ SILFG 366_ HENRV 371_ STLRV 376_ SPDGT 381_ AFCSG 386_SWDHT
1: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (PubMed:27677260). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity)