Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
1_MKRSS 6_ VSSGG 11_ AGRLS 16_ MQELR 21_ SQDVN 26_ KQGLY 31_ TPQTK 36_ EKPTF 41_ GKLSI 46_ NKPTS 51_ ERKVS 56_ LFGKR 61_ TSGHG 66_ SRNSQ 71_ LGIFS 76_ SSEKI 81_ KDPRP 86_ LNDKA 91_ FIQQC 96_ IRQLC 101_ EFLTE 106_ NGYAH 111_ NVSMK 116_ SLQAP 121_ SVKDF 126_ LKIFT 131_ FLYGF 136_ LCPSY 141_ ELPDT 146_ KFEEE 151_ VPRIF 156_ KDLGY 161_ PFALS 166_ KSSMY 171_ TVGAP 176_ HTWPH 181_ IVAAL 186_ VWLID 191_ CIKIH 196_ TAMKE 201_ SSPLF 206_ DDGQP 211_ WGEET 216_ EDGIM 221_ HNKLF 226_ LDYTI 231_ KCYES 236_ FMSGA 241_ DSFDE 246_ MNAEL 251_ QSKLK 256_ DLFNV 261_ DAFKL 266_ ESLEA 271_ KNRAL 276_ NEQIA 281_ RLEQE 286_ REKEP 291_ NRLES 296_ LRKLK 301_ ASLQG 306_ DVQKY 311_ QAYMS 316_ NLESH 321_ SAILD 326_ QKLNG 331_ LNEEI 336_ ARVEL 341_ ECETI 346_ KQENT 351_ RLQNI 356_ IDNQK 361_ YSVAD 366_ IERIN 371_ HERNE 376_ LQQTI 381_ NKLTK 386_ DLEAE 391_ QQKLW 396_ NEELK 401_ YARGK 406_ EAIET 411_ QLAEY 416_ HKLAR 421_ KLKLI 426_ PKGAE 431_ NSKGY 436_ DFEIK 441_ FNPEA 446_ GANCL 451_ VKYRA 456_ QVYVP 461_ LKELL 466_ NETEE 471_ EINKA 476_ LNKKM 481_ GLEDT 486_ LEQLN 491_ AMITE 496_ SKRSV 501_ RTLKE 506_ EVQKL 511_ DDLYQ 516_ QKIKE 521_ AEEED 526_ EKCAS 531_ ELESL 536_ EKHKH 541_ LLEST 546_ VNQGL 551_ SEAMN 556_ ELDAV 561_ QREYQ 566_ LVVQT 571_ TTEER 576_ RKVGN 581_ NLQRL 586_ LEMVA 591_ THVGS 596_ VEKHL 601_ EEQIA 606_ KVDRE 611_ YEECM 616_ SEDLS 621_ ENIKE 626_ IRDKY 631_ EKKAT 636_LIKSS
1: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327, PubMed:30409912, PubMed:9315664). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592, PubMed:30409912). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:23891108, PubMed:25743205)