Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
1_MERGL 6_ PLLCA 11_ VLALV 16_ LAPAG 21_ AFRND 26_ KCGDT 31_ IKIES 36_ PGYLT 41_ SPGYP 46_ HSYHP 51_ SEKCE 56_ WLIQA 61_ PDPYQ 66_ RIMIN 71_ FNPHF 76_ DLEDR 81_ DCKYD 86_ YVEVF 91_ DGENE 96_ NGHFR 101_ GKFCG 106_ KIAPP 111_ PVVSS 116_ GPFLF 121_ IKFVS 126_ DYETH 131_ GAGFS 136_ IRYEI 141_ FKRGP 146_ ECSQN 151_ YTTPS 156_ GVIKS 161_ PGFPE 166_ KYPNS 171_ LECTY 176_ IVFVP 181_ KMSEI 186_ ILEFE 191_ SFDLE 196_ PDSNP 201_ PGGMF 206_ CRYDR 211_ LEIWD 216_ GFPDV 221_ GPHIG 226_ RYCGQ 231_ KTPGR 236_ IRSSS 241_ GILSM 246_ VFYTD 251_ SAIAK 256_ EGFSA 261_ NYSVL 266_ QSSVS 271_ EDFKC 276_ MEALG 281_ MESGE 286_ IHSDQ 291_ ITASS 296_ QYSTN 301_ WSAER 306_ SRLNY 311_ PENGW 316_ TPGED 321_ SYREW 326_ IQVDL 331_ GLLRF 336_ VTAVG 341_ TQGAI 346_ SKETK 351_ KKYYV 356_ KTYKI 361_ DVSSN 366_ GEDWI 371_ TIKEG 376_ NKPVL 381_ FQGNT 386_ NPTDV 391_ VVAVF 396_ PKPLI 401_ TRFVR 406_ IKPAT 411_ WETGI 416_ SMRFE 421_ VYGCK 426_ ITDYP 431_ CSGML 436_ GMVSG 441_ LISDS 446_ QITSS 451_ NQGDR 456_ NWMPE 461_ NIRLV 466_ TSRSG 471_ WALPP 476_ APHSY 481_ INEWL 486_ QIDLG 491_ EEKIV 496_ RGIII 501_ QGGKH 506_ RENKV 511_ FMRKF 516_ KIGYS 521_ NNGSD 526_ WKMIM 531_ DDSKR 536_ KAKSF 541_ EGNNN 546_ YDTPE 551_ LRTFP 556_ ALSTR 561_ FIRIY 566_ PERAT 571_ HGGLG 576_ LRMEL 581_ LGCEV 586_ EAPTA 591_ GPTTP 596_ NGNLV 601_ DECDD 606_ DQANC 611_ HSGTG 616_ DDFQL 621_ TGGTT 626_ VLATE 631_ KPTVI 636_ DSTIQ 641_ SEFPT 646_ YGFNC 651_ EFGWG 656_ SHKTF 661_ CHWEH 666_ DNHVQ 671_ LKWSV 676_ LTSKT 681_ GPIQD 686_ HTGDG 691_ NFIYS 696_ QADEN 701_ QKGKV 706_ ARLVS 711_ PVVYS 716_ QNSAH 721_ CMTFW 726_ YHMSG 731_ SHVGT 736_ LRVKL 741_ RYQKP 746_ EEYDQ 751_ LVWMA 756_ IGHQG 761_ DHWKE 766_ GRVLL 771_ HKSLK 776_ LYQVI 781_ FEGEI 786_ GKGNL 791_ GGIAV 796_ DDISI 801_ NNHIS 806_ QEDCA 811_ KPADL 816_ DKKNP 821_ EIKID 826_ ETGST 831_ PGYEG 836_ EGEGD 841_ KNISR 846_ KPGNV 851_ LKTLD 856_ PILIT 861_ IIAMS 866_ ALGVL 871_ LGAVC 876_ GVVLY 881_ CACWH 886_ NGMSE 891_ RNLSA 896_ LENYN 901_ FELVD 906_ GVKLK 911_ KDKLN 916_TQSTY
1: Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:10688880, PubMed:9288753, PubMed:9529250). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:10688880, PubMed:19805273, PubMed:9288753, PubMed:9529250). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799)
2: (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection
3: Binds VEGF-165 and may inhibit its binding to cells (PubMed:10748121, PubMed:26503042). May induce apoptosis by sequestering VEGF-165 (PubMed:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity