Transportin-2 (Karyopherin beta-2b)
1_MDWQP 6_ DEQGL 11_ QQVLQ 16_ LLKDS 21_ QSPNT 26_ ATQRI 31_ VQDKL 36_ KQLNQ 41_ FPDFN 46_ NYLIF 51_ VLTRL 56_ KSEDE 61_ PTRSL 66_ SGLIL 71_ KNNVK 76_ AHYQS 81_ FPPPV 86_ ADFIK 91_ QECLN 96_ NIGDA 101_ SSLIR 106_ ATIGI 111_ LITTI 116_ ASKGE 121_ LQMWP 126_ ELLPQ 131_ LCNLL 136_ NSEDY 141_ NTCEG 146_ AFGAL 151_ QKICE 156_ DSSEL 161_ LDSDA 166_ LNRPL 171_ NIMIP 176_ KFLQF 181_ FKHCS 186_ PKIRS 191_ HAIAC 196_ VNQFI 201_ MDRAQ 206_ ALMDN 211_ IDTFI 216_ EHLFA 221_ LAVDD 226_ DPEVR 231_ KNVCR 236_ ALVML 241_ LEVRI 246_ DRLIP 251_ HMHSI 256_ IQYML 261_ QRTQD 266_ HDENV 271_ ALEAC 276_ EFWLT 281_ LAEQP 286_ ICKEV 291_ LASHL 296_ VQLIP 301_ ILVNG 306_ MKYSE 311_ IDIIL 316_ LKGDV 321_ EEDEA 326_ VPDSE 331_ QDIKP 336_ RFHKS 341_ RTVTL 346_ PHEAE 351_ RPDGS 356_ EDAED 361_ DDDDD 366_ ALSDW 371_ NLRKC 376_ SAAAL 381_ DVLAN 386_ VFREE 391_ LLPHL 396_ LPLLK 401_ GLLFH 406_ PEWVV 411_ KESGI 416_ LVLGA 421_ IAEGC 426_ MQGMV 431_ PYLPE 436_ LIPHL 441_ IQCLS 446_ DKKAL 451_ VRSIA 456_ CWTLS 461_ RYAHW 466_ VVSQP 471_ PDMHL 476_ KPLMT 481_ ELLKR 486_ ILDGN 491_ KRVQE 496_ AACSA 501_ FATLE 506_ EEACT 511_ ELVPY 516_ LSYIL 521_ DTLVF 526_ AFGKY 531_ QHKNL 536_ LILYD 541_ AIGTL 546_ ADSVG 551_ HHLNQ 556_ PEYIQ 561_ KLMPP 566_ LIQKW 571_ NELKD 576_ EDKDL 581_ FPLLE 586_ CLSSV 591_ ATALQ 596_ SGFLP 601_ YCEPV 606_ YQRCV 611_ TLVQK 616_ TLAQA 621_ MMYTQ 626_ HPEQY 631_ EAPDK 636_ DFMIV 641_ ALDLL 646_ SGLAE 651_ GLGGH 656_ VEQLV 661_ ARSNI 666_ MTLLF 671_ QCMQD 676_ SMPEV 681_ RQSSF 686_ ALLGD 691_ LTKAC 696_ FIHVK 701_ PCIAE 706_ FMPIL 711_ GTNLN 716_ PEFIS 721_ VCNNA 726_ TWAIG 731_ EICMQ 736_ MGAEM 741_ QPYVQ 746_ MVLNN 751_ LVEII 756_ NRPNT 761_ PKTLL 766_ ENTGR 771_ LTSPS 776_ AIPAI 781_ TIGRL 786_ GYVCP 791_ QEVAP 796_ MLQQF 801_ IRPWC 806_ TSLRN 811_ IRDNE 816_ EKDSA 821_ FRGIC 826_ MMIGV 831_ NPGGV 836_ VQDFI 841_ FFCDA 846_ VASWV 851_ SPKDD 856_ LRDMF 861_ YKILH 866_ GFKDQ 871_ VGEDN 876_ WQQFS 881_ EQFPP 886_ LLKER 891_LAAFY
1: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity)