Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
1_MRRAS 6_ RDYTK 11_ YLRGS 16_ EEMGG 21_ GPGAP 26_ HEGPL 31_ HAPPP 36_ PAPHQ 41_ PPAAS 46_ RSMFV 51_ ALLGL 56_ GLGQV 61_ VCSVA 66_ LFFYF 71_ RAQMD 76_ PNRIS 81_ EDGTH 86_ CIYRI 91_ LRLHE 96_ NADFQ 101_ DTTLE 106_ SQDTK 111_ LIPDS 116_ CRRIK 121_ QAFQG 126_ AVQKE 131_ LQHIV 136_ GSQHI 141_ RAEKA 146_ MVDGS 151_ WLDLA 156_ KRSKL 161_ EAQPF 166_ AHLTI 171_ NATDI 176_ PSGSH 181_ KVSLS 186_ SWYHD 191_ RGWAK 196_ ISNMT 201_ FSNGK 206_ LIVNQ 211_ DGFYY 216_ LYANI 221_ CFRHH 226_ ETSGD 231_ LATEY 236_ LQLMV 241_ YVTKT 246_ SIKIP 251_ SSHTL 256_ MKGGS 261_ TKYWS 266_ GNSEF 271_ HFYSI 276_ NVGGF 281_ FKLRS 286_ GEEIS 291_ IEVSN 296_ PSLLD 301_ PDQDA 306_ TYFGA 311_FKVRD
1: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity)