Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1) (3-OST-1) (Heparan sulfate 3-O-sulfotransferase 1) (h3-OST-1)
1_MAALL 6_ LGAVL 11_ LVAQP 16_ QLVPS 21_ RPAEL 26_ GQQEL 31_ LRKAG 36_ TLQDD 41_ VRDGV 46_ APNGS 51_ AQQLP 56_ QTIII 61_ GVRKG 66_ GTRAL 71_ LEMLS 76_ LHPDV 81_ AAAEN 86_ EVHFF 91_ DWEEH 96_ YSHGL 101_ GWYLS 106_ QMPFS 111_ WPHQL 116_ TVEKT 121_ PAYFT 126_ SPKVP 131_ ERVYS 136_ MNPSI 141_ RLLLI 146_ LRDPS 151_ ERVLS 156_ DYTQV 161_ FYNHM 166_ QKHKP 171_ YPSIE 176_ EFLVR 181_ DGRLN 186_ VDYKA 191_ LNRSL 196_ YHVHM 201_ QNWLR 206_ FFPLR 211_ HIHIV 216_ DGDRL 221_ IRDPF 226_ PEIQK 231_ VERFL 236_ KLSPQ 241_ INASN 246_ FYFNK 251_ TKGFY 256_ CLRDS 261_ GRDRC 266_ LHESK 271_ GRAHP 276_ QVDPK 281_ LLNKL 286_ HEYFH 291_ EPNKK 296_ FFELV 301_GRTFD
1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:8900198, PubMed:9346953, PubMed:9988768). Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:8900198, PubMed:9988768). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (PubMed:8900198, PubMed:9988768)