SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
1_MDLPY 6_ YHGRL 11_ TKQDC 16_ ETLLL 21_ KEGVD 26_ GNFLL 31_ RDSES 36_ IPGVL 41_ CLCVS 46_ FKNIV 51_ YTYRI 56_ FREKH 61_ GYYRI 66_ QTAEG 71_ SPKQV 76_ FPSLK 81_ ELISK 86_ FEKPN 91_ QGMVV 96_ HLLKP 101_ IKRTS 106_ PSLRW 111_ RGLKL 116_ ELETF 121_ VNSNS 126_DYVDV
1: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity)