DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)
1_MVKEQ 6_ FRETD 11_ VAKKI 16_ SHICF 21_ GMKSP 26_ EEMRQ 31_ QAHIQ 36_ VVSKN 41_ LYSQD 46_ NQHAP 51_ LLYGV 56_ LDHRM 61_ GTSEK 66_ DRPCE 71_ TCGKN 76_ LADCL 81_ GHYGY 86_ IDLEL 91_ PCFHV 96_ GYFRA 101_ VIGIL 106_ QMICK 111_ TCCHI 116_ MLSQE 121_ EKKQF 126_ LDYLK 131_ RPGLT 136_ YLQKR 141_ GLKKK 146_ ISDKC 151_ RKKNI 156_ CHHCG 161_ AFNGT 166_ VKKCG 171_ LLKII 176_ HEKYK 181_ TNKKV 186_ VDPIV 191_ SNFLQ 196_ SFETA 201_ IEHNK 206_ EVEPL 211_ LGRAQ 216_ ENLNP 221_ LVVLN 226_ LFKRI 231_ PAEDV 236_ PLLLM 241_ NPEAG 246_ KPSDL 251_ ILTRL 256_ LVPPL 261_ CIRPS 266_ VVSDL 271_ KSGTN 276_ EDDLT 281_ MKLTE 286_ IIFLN 291_ DVIKK 296_ HRISG 301_ AKTQM 306_ IMEDW 311_ DFLQL 316_ QCALY 321_ INSEL 326_ SGIPL 331_ NMAPK 336_ KWTRG 341_ FVQRL 346_ KGKQG 351_ RFRGN 356_ LSGKR 361_ VDFSG 366_ RTVIS 371_ PDPNL 376_ RIDEV 381_ AVPVH 386_ VAKIL 391_ TFPEK 396_ VNKAN 401_ INFLR 406_ KLVQN 411_ GPEVH 416_ PGANF 421_ IQQRH 426_ TQMKR 431_ FLKYG 436_ NREKM 441_ AQELK 446_ YGDIV 451_ ERHLI 456_ DGDVV 461_ LFNRQ 466_ PSLHK 471_ LSIMA 476_ HLARV 481_ KPHRT 486_ FRFNE 491_ CVCTP 496_ YNADF 501_ DGDEM 506_ NLHLP 511_ QTEEA 516_ KAEAL 521_ VLMGT 526_ KANLV 531_ TPRNG 536_ EPLIA 541_ AIQDF 546_ LTGAY 551_ LLTLK 556_ DTFFD 561_ RAKAC 566_ QIIAS 571_ ILVGK 576_ DEKIK 581_ VRLPP 586_ PTILK 591_ PVTLW 596_ TGKQI 601_ FSVIL 606_ RPSDD 611_ NPVRA 616_ NLRTK 621_ GKQYC 626_ GKGED 631_ LCAND 636_ SYVTI 641_ QNSEL 646_ MSGSM 651_ DKGTL 656_ GSGSK 661_ NNIFY 666_ ILLRD 671_ WGQNE 676_ AADAM 681_ SRLAR 686_ LAPVY 691_ LSNRG 696_ FSIGI 701_ GDVTP 706_ GQGLL 711_ KAKYE 716_ LLNAG 721_ YKKCD 726_ EYIEA 731_ LNTGK 736_ LQQQP 741_ GCTAE 746_ ETLEA 751_ LILKE 756_ LSVIR 761_ DHAGS 766_ ACLRE 771_ LDKSN 776_ SPLTM 781_ ALCGS 786_ KGSFI 791_ NISQM 796_ IACVG 801_ QQAIS 806_ GSRVP 811_ DGFEN 816_ RSLPH 821_ FEKHS 826_ KLPAA 831_ KGFVA 836_ NSFYS 841_ GLTPT 846_ EFFFH 851_ TMAGR 856_ EGLVD 861_ TAVKT 866_ AETGY 871_ MQRRL 876_ VKSLE 881_ DLCSQ 886_ YDLTV 891_ RSSTG 896_ DIIQF 901_ IYGGD 906_ GLDPA 911_ AMEGK 916_ DEPLE 921_ FKRVL 926_ DNIKA 931_ VFPCP 936_ SEPAL 941_ SKNEL 946_ ILTTE 951_ SIMKK 956_ SEFLC 961_ CQDSF 966_ LQEIK 971_ KFIKG 976_ VSEKI 981_ KKTRD 986_ KYGIN 991_ DNGTT 996_ EPRVL 1001_ YQLDR 1006_ ITPTQ 1011_ VEKFL 1016_ ETCRD 1021_ KYMRA 1026_ QMEPG 1031_ SAVGA 1036_ LCAQS 1041_ IGEPG 1046_ TQMTL 1051_ KTFHF 1056_ AGVAS 1061_ MNITL 1066_ GVPRI 1071_ KEIIN 1076_ ASKAI 1081_ STPII 1086_ TAQLD 1091_ KDDDA 1096_ DYARL 1101_ VKGRI 1106_ EKTLL 1111_ GEISE 1116_ YIEEV 1121_ FLPDD 1126_ CFILV 1131_ KLSLE 1136_ RIRLL 1141_ RLEVN 1146_ AETVR 1151_ YSICT 1156_ SKLRV 1161_ KPGDV 1166_ AVHGE 1171_ AVVCV 1176_ TPREN 1181_ SKSSM 1186_ YYVLQ 1191_ FLKED 1196_ LPKVV 1201_ VQGIP 1206_ EVSRA 1211_ VIHID 1216_ EQSGK 1221_ EKYKL 1226_ LVEGD 1231_ NLRAV 1236_ MATHG 1241_ VKGTR 1246_ TTSNN 1251_ TYEVE 1256_ KTLGI 1261_ EAART 1266_ TIINE 1271_ IQYTM 1276_ VNHGM 1281_ SIDRR 1286_ HVMLL 1291_ SDLMT 1296_ YKGEV 1301_ LGITR 1306_ FGLAK 1311_ MKESV 1316_ LMLAS 1321_ FEKTA 1326_ DHLFD 1331_ AAYFG 1336_ QKDSV 1341_ CGVSE 1346_ CIIMG 1351_ IPMNI 1356_ GTGLF 1361_ KLLHK 1366_ ADRDP 1371_ NPPKR 1376_ PLIFD 1381_TNEFH
1: Catalytic core component of RNA polymerase III (Pol III), a DNA-dependent RNA polymerase which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Synthesizes 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:19609254, PubMed:19631370, PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:34675218, PubMed:35637192, PubMed:9331371). Pol III-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol III is recruited to DNA promoters type I, II or III with the help of general transcription factors and other specific initiation factors. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Transcription termination involves the release of the RNA transcript and polymerase from the DNA (PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33558766, PubMed:33674783, PubMed:34675218). Forms Pol III active center together with the second largest subunit POLR3B/RPC2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR3A/RPC1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR3B/RPC2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate (PubMed:19609254, PubMed:20413673, PubMed:33335104, PubMed:33558764, PubMed:33674783, PubMed:34675218, PubMed:9331371). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway