Ras-related protein M-Ras (EC 3.6.5.2) (Ras-related protein R-Ras3)
1_MATSA 6_ VPSDN 11_ LPTYK 16_ LVVVG 21_ DGGVG 26_ KSALT 31_ IQFFQ 36_ KIFVP 41_ DYDPT 46_ IEDSY 51_ LKHTE 56_ IDNQW 61_ AILDV 66_ LDTAG 71_ QEEFS 76_ AMREQ 81_ YMRTG 86_ DGFLI 91_ VYSVT 96_ DKASF 101_ EHVDR 106_ FHQLI 111_ LRVKD 116_ RESFP 121_ MILVA 126_ NKVDL 131_ MHLRK 136_ ITREQ 141_ GKEMA 146_ TKHNI 151_ PYIET 156_ SAKDP 161_ PLNVD 166_ KAFHD 171_ LVRVI 176_ RQQIP 181_ EKSQK 186_ KKKKT 191_ KWRGD 196_ RATGT 201_HKLQC
1: Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:16630891, PubMed:28289718, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). The formation of the SMP complex only occurs when MRAS is GTP-bound (PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670, PubMed:39809765). MRAS has low intrinsic GTPase activity and may require additional factors for activation (PubMed:39809765). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:16630891, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670)