Complexin-1 (Complexin I) (CPX I) (Synaphin-2)
1_MEFVM 6_ KQALG 11_ GATKD 16_ MGKML 21_ GGDEE 26_ KDPDA 31_ AKKEE 36_ ERQEA 41_ LRQAE 46_ EERKA 51_ KYAKM 56_ EAERE 61_ AVRQG 66_ IRDKY 71_ GIKKK 76_ EEREA 81_ EAQAA 86_ MEANS 91_ EGSLT 96_ RPKKA 101_ IPPGC 106_ GDEVE 111_ EEDES 116_ ILDTV 121_ IKYLP 126_GPLQD
1: Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior