Tetraspanin-4 (Tspan-4) (Novel antigen 2) (NAG-2) (Transmembrane 4 superfamily member 7)
1_MARAC 6_ LQAVK 11_ YLMFA 16_ FNLLF 21_ WLGGC 26_ GVLGV 31_ GIWLA 36_ ATQGS 41_ FATLS 46_ SSFPS 51_ LSAAN 56_ LLIIT 61_ GAFVM 66_ AIGFV 71_ GCLGA 76_ IKENK 81_ CLLLT 86_ FFLLL 91_ LLVFL 96_ LEATI 101_ AILFF 106_ AYTDK 111_ IDRYA 116_ QQDLK 121_ KGLHL 126_ YGTQG 131_ NVGLT 136_ NAWSI 141_ IQTDF 146_ RCCGV 151_ SNYTD 156_ WFEVY 161_ NATRV 166_ PDSCC 171_ LEFSE 176_ SCGLH 181_ APGTW 186_ WKAPC 191_ YETVK 196_ VWLQE 201_ NLLAV 206_ GIFGL 211_ CTALV 216_ QILGL 221_ TFAMT 226_ MYCQV 231_VKADT
1: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays an essential role in migrasome formation and migration on retracting fibers at the rear end of migrating cells (PubMed:31371828). Migrasomes are cellular organelles that form as large vesicle-like structures on retraction fibers of migrating cells (PubMed:31371828). Mechanistically, acts as a membrane curvature sensor and participates in stabilizing the migrasome structure in a late stage of biogenesis (PubMed:36252000, PubMed:36823145). May also play a regulatory role for the histamine H4 receptor/HRH4 without affecting histamine binding to HRH4 or signaling (PubMed:34439793)