Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7)
1_MSYDR 6_ AITVF 11_ SPDGH 16_ LFQVE 21_ YAQEA 26_ VKKGS 31_ TAVGV 36_ RGRDI 41_ VVLGV 46_ EKKSV 51_ AKLQD 56_ ERTVR 61_ KICAL 66_ DDNVC 71_ MAFAG 76_ LTADA 81_ RIVIN 86_ RARVE 91_ CQSHR 96_ LTVED 101_ PVTVE 106_ YITRY 111_ IASLK 116_ QRYTQ 121_ SNGRR 126_ PFGIS 131_ ALIVG 136_ FDFDG 141_ TPRLY 146_ QTDPS 151_ GTYHA 156_ WKANA 161_ IGRGA 166_ KSVRE 171_ FLEKN 176_ YTDEA 181_ IETDD 186_ LTIKL 191_ VIKAL 196_ LEVVQ 201_ SGGKN 206_ IELAV 211_ MRRDQ 216_ SLKIL 221_ NPEEI 226_ EKYVA 231_ EIEKE 236_ KEENE 241_KKKQK
1: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response