Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2)
1_MQKSV 6_ RYNEG 11_ HALYL 16_ AFLAR 21_ KEGTK 26_ RGFLS 31_ KKTAE 36_ ASRWH 41_ EKWFA 46_ LYQNV 51_ LFYFE 56_ GEQSC 61_ RPAGM 66_ YLLEG 71_ CSCER 76_ TPAPP 81_ RAGAG 86_ QGGVR 91_ DALDK 96_ QYYFT 101_ VLFGH 106_ EGQKP 111_ LELRC 116_ EEEQD 121_ GKEWM 126_ EAIHQ 131_ ASYAD 136_ ILIER 141_ EVLMQ 146_ KYIHL 151_ VQIVE 156_ TEKIA 161_ ANQLR 166_ HQLED 171_ QDTEI 176_ ERLKS 181_ EIIAL 186_ NKTKE 191_ RMRPY 196_ QSNQE 201_ DEDPD 206_ IKKIK 211_ KVQSF 216_ MRGWL 221_ CRRKW 226_ KTIVQ 231_ DYICS 236_ PHAES 241_ MRKRN 246_ QIVFT 251_ MVEAE 256_ SEYVH 261_ QLYIL 266_ VNGFL 271_ RPLRM 276_ AASSK 281_ KPPIS 286_ HDDVS 291_ SIFLN 296_ SETIM 301_ FLHEI 306_ FHQGL 311_ KARIA 316_ NWPTL 321_ ILADL 326_ FDILL 331_ PMLNI 336_ YQEFV 341_ RNHQY 346_ SLQVL 351_ ANCKQ 356_ NRDFD 361_ KLLKQ 366_ YEANP 371_ ACEGR 376_ MLETF 381_ LTYPM 386_ FQIPR 391_ YIITL 396_ HELLA 401_ HTPHE 406_ HVERK 411_ SLEFA 416_ KSKLE 421_ ELSRV 426_ MHDEV 431_ SDTEN 436_ IRKNL 441_ AIERM 446_ IVEGC 451_ DILLD 456_ TSQTF 461_ IRQGS 466_ LIQVP 471_ SVERG 476_ KLSKV 481_ RLGSL 486_ SLKKE 491_ GERQC 496_ FLFTK 501_ HFLIC 506_ TRSSG 511_ GKLHL 516_ LKTGG 521_ VLSLI 526_ DCTLI 531_ EEPDA 536_ SDDDS 541_ KGSGQ 546_ VFGHL 551_ DFKIV 556_ VEPPD 561_ AAAFT 566_ VVLLA 571_ PSRQE 576_ KAAWM 581_ SDISQ 586_ CVDNI 591_ RCNGL 596_ MTIVF 601_ EENSK 606_ VTVPH 611_ MIKSD 616_ ARLHK 621_ DDTDI 626_ CFSKT 631_ LNSCK 636_ VPQIR 641_ YASVE 646_ RLLER 651_ LTDLR 656_ FLSID 661_ FLNTF 666_ LHTYR 671_ IFTTA 676_ AVVLG 681_ KLSDI 686_ YKRPF 691_ TSIPV 696_ RSLEL 701_ FFATS 706_ QNNRG 711_ EHLVD 716_ GKSPR 721_ LCRKF 726_ SSPPP 731_ LAVSR 736_ TSSPV 741_ RARKL 746_ SLTSP 751_ LNSKI 756_ GALDL 761_ TTSSS 766_ PTTTT 771_ QSPAA 776_ SPPPH 781_ TGQIP 786_ LDLSR 791_ GLSSP 796_ EQSPG 801_ TVEEN 806_ VDNPR 811_ VDLCN 816_ KLKRS 821_ IQKAV 826_ LESAP 831_ ADRAG 836_ VESSP 841_ AADTT 846_ ELSPC 851_ RSPST 856_ PRHLR 861_ YRQPG 866_ GQTAD 871_ NAHCS 876_ VSPAS 881_ AFAIA 886_ TAAAG 891_ HGSPP 896_ GFNNT 901_ ERTCD 906_ KEFII 911_ RRTAT 916_ NRVLN 921_ VLRHW 926_ VSKHA 931_ QDFEL 936_ NNELK 941_ MNVLN 946_ LLEEV 951_ LRDPD 956_ LLPQE 961_ RKAAA 966_ NILRA 971_ LSQDD 976_ QDDIH 981_ LKLED 986_ IIQMT 991_ DCMKA 996_ ECFES 1001_ LSAME 1006_ LAEQI 1011_ TLLDH 1016_ VIFRS 1021_ IPYEE 1026_ FLGQG 1031_ WMKLD 1036_ KNERT 1041_ PYIMK 1046_ TSQHF 1051_ NDMSN 1056_ LVASQ 1061_ IMNYA 1066_ DVSSR 1071_ ANAIE 1076_ KWVAV 1081_ ADICR 1086_ CLHNY 1091_ NGVLE 1096_ ITSAL 1101_ NRSAI 1106_ YRLKK 1111_ TWAKV 1116_ SKQTK 1121_ ALMDK 1126_ LQKTV 1131_ SSEGR 1136_ FKNLR 1141_ ETLKN 1146_ CNPPA 1151_ VPYLG 1156_ MYLTD 1161_ LAFIE 1166_ EGTPN 1171_ FTEEG 1176_ LVNFS 1181_ KMRMI 1186_ SHIIR 1191_ EIRQF 1196_ QQTSY 1201_ RIDHQ 1206_ PKVAQ 1211_ YLLDK 1216_ DLIID 1221_ EDTLY 1226_ ELSLK 1231_IEPRL
1: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation