Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G)
1_MSEVT 6_ KNSLE 11_ KILPQ 16_ LKCHF 21_ TWNLF 26_ KEDSV 31_ SRDLE 36_ DRVCN 41_ QIEFL 46_ NTEFK 51_ ATMYN 56_ LLAYI 61_ KHLDG 66_ NNEAA 71_ LECLR 76_ QAEEL 81_ IQQEH 86_ ADQAE 91_ IRSLV 96_ TWGNY 101_ AWVYY 106_ HLGRL 111_ SDAQI 116_ YVDKV 121_ KQTCK 126_ KFSNP 131_ YSIEY 136_ SELDC 141_ EEGWT 146_ QLKCG 151_ RNERA 156_ KVCFE 161_ KALEE 166_ KPNNP 171_ EFSSG 176_ LAIAM 181_ YHLDN 186_ HPEKQ 191_ FSTDV 196_ LKQAI 201_ ELSPD 206_ NQYVK 211_ VLLGL 216_ KLQKM 221_ NKEAE 226_ GEQFV 231_ EEALE 236_ KSPCQ 241_ TDVLR 246_ SAAKF 251_ YRRKG 256_ DLDKA 261_ IELFQ 266_ RVLES 271_ TPNNG 276_ YLYHQ 281_ IGCCY 286_ KAKVR 291_ QMQNT 296_ GESEA 301_ SGNKE 306_ MIEAL 311_ KQYAM 316_ DYSNK 321_ ALEKG 326_ LNPLN 331_ AYSDL 336_ AEFLE 341_ TECYQ 346_ TPFNK 351_ EVPDA 356_ EKQQS 361_ HQRYC 366_ NLQKY 371_ NGKSE 376_ DTAVQ 381_ HGLEG 386_ LSISK 391_ KSTDK 396_ EEIKD 401_ QPQNV 406_ SENLL 411_ PQNAP 416_ NYWYL 421_ QGLIH 426_ KQNGD 431_ LLQAA 436_ KCYEK 441_ ELGRL 446_ LRDAP 451_ SGIGS 456_ IFLSA 461_ SELED 466_ GSEEM 471_ GQGAV 476_ SSSPR 481_ELLSN
1: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2