Microsomal glutathione S-transferase 3 (Microsomal GST-3) (Glutathione peroxidase MGST3) (EC 1.11.1.-) (LTC4 synthase MGST3) (EC 4.4.1.20) (Microsomal glutathione S-transferase III) (Microsomal GST-III)
1_MAVLS 6_ KEYGF 11_ VLLTG 16_ AASFI 21_ MVAHL 26_ AINVS 31_ KARKK 36_ YKVEY 41_ PIMYS 46_ TDPEN 51_ GHIFN 56_ CIQRA 61_ HQNTL 66_ EVYPP 71_ FLFFL 76_ AVGGV 81_ YHPRI 86_ ASGLG 91_ LAWIV 96_ GRVLY 101_ AYGYY 106_ TGEPS 111_ KRSRG 116_ ALGSI 121_ ALLGL 126_ VGTTV 131_ CSAFQ 136_ HLGWV 141_ KSGLG 146_SGPKC
1: Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites (PubMed:36370807, PubMed:9278457). Catalyzes conjugate addition of reduced glutathione to the alpha, beta-unsaturated C=C carbonyl group of eisosanoids such as leukotriene A4 and 15-deoxy-Delta12,14-prostaglandin J2 to form GSH adducts relevant to the inflammatory response (PubMed:36370807, PubMed:9278457). Catalyzes glutathione-dependent reduction of eicosanoid peroxides to yield the corresponding eicosanoid hydroxides (PubMed:9278457)