Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H)
1_MCTGK 6_ CARCV 11_ GLSLI 16_ TLCLV 21_ CIVAN 26_ ALLLV 31_ PNGET 36_ SWTNT 41_ NHLSL 46_ QVWLM 51_ GGFIG 56_ GGLMV 61_ LCPGI 66_ AAVRA 71_ GGKGC 76_ CGAGC 81_ CGNRC 86_ RMLRS 91_ VFSSA 96_ FGVLG 101_ AIYCL 106_ SVSGA 111_ GLRNG 116_ PRCLM 121_ NGEWG 126_ YHFED 131_ TAGAY 136_ LLNRT 141_ LWDRC 146_ EAPPR 151_ VVPWN 156_ VTLFS 161_ LLVAA 166_ SCLEI 171_ VLCGI 176_ QLVNA 181_ TIGVF 186_ CGDCR 191_KKQDT
1: Acts as a lysosomal membrane arginine sensor (PubMed:30956113). Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations (PubMed:30956113). Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus (PubMed:20399237). CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression (PubMed:20399237)