Protein lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Tax interaction protein 33) (TIP-33) (Vertebrate lin-7 homolog 1) (Veli-1)
1_MLKPS 6_ VTSAP 11_ TADMA 16_ TLTVV 21_ QPLTL 26_ DRDVA 31_ RAIEL 36_ LEKLQ 41_ ESGEV 46_ PVHKL 51_ QSLKK 56_ VLQSE 61_ FCTAI 66_ REVYQ 71_ YMHET 76_ ITVNG 81_ CPEFR 86_ ARATA 91_ KATVA 96_ AFAAS 101_ EGHSH 106_ PRVVE 111_ LPKTD 116_ EGLGF 121_ NVMGG 126_ KEQNS 131_ PIYIS 136_ RIIPG 141_ GVAER 146_ HGGLK 151_ RGDQL 156_ LSVNG 161_ VSVEG 166_ EHHEK 171_ AVELL 176_ KAAKD 181_ SVKLV 186_ VRYTP 191_ KVLEE 196_ MEARF 201_ EKLRT 206_ ARRRQ 211_ QQQLL 216_ IQQQQ 221_ QQQQQ 226_QTQQN
1: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells