Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1)
1_MAGFG 6_ AMEKF 11_ LVEYK 16_ SAVEK 21_ KLAEY 26_ KCNTN 31_ TAIEL 36_ KLVRF 41_ PEDLE 46_ NDIRT 51_ FFPEY 56_ THQLF 61_ GDDET 66_ AFGYK 71_ GLKIL 76_ LYYIA 81_ GSLST 86_ MFRVE 91_ YASKV 96_ DENFD 101_ CVEAD 106_ DVEGK 111_ IRQII 116_ PPGFC 121_ TNTND 126_ FLSLL 131_ EKEVD 136_ FKPFG 141_ TLLHT 146_ YSVLS 151_ PTGGE 156_ NFTFQ 161_ IYKAD 166_ MTCRG 171_ FREYH 176_ ERLQT 181_ FLMWF 186_ IETAS 191_ FIDVD 196_ DERWH 201_ YFLVF 206_ EKYNK 211_ DGATL 216_ FATVG 221_ YMTVY 226_ NYYVY 231_ PDKTR 236_ PRVSQ 241_ MLILT 246_ PFQGQ 251_ GHGAQ 256_ LLETV 261_ HRYYT 266_ EFPTV 271_ LDITA 276_ EDPSK 281_ SYVKL 286_ RDFVL 291_ VKLCQ 296_ DLPCF 301_ SREKL 306_ MQGFN 311_ EDMVI 316_ EAQQK 321_ FKINK 326_ QHARR 331_ VYEIL 336_ RLLVT 341_ DMSDA 346_ EQYRS 351_ YRLDI 356_ KRRLI 361_ SPYKK 366_ KQRDL 371_ AKMRK 376_ CLRPE 381_ ELTNQ 386_ MNQIE 391_ ISMQH 396_ EQLEE 401_ SFQEL 406_ VEDYR 411_RVIER
1: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:20953179, PubMed:23653357, PubMed:31278053, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:11585814, PubMed:22615379). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350)
2: (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell